acute myeloid leukemia (aml) is a cancer of the myeloid line of blood cells that infiltrate the bone marrow, blood, and other tissues . they include bioactive compounds that have the potential for prevention or treatment of major diseases and have been used as therapeutic medicine in human history [7,8,9]. in this review, potent anti-aml natural compounds were classified and reviewed by a mechanism of actions. treatment of aromatic-tumerone separated from turmeric oil upregulates the expression of bax, p53, c-caspase-3 and cytochrome c release . the treatment of anthraquinone, extracted from hedyotis diffusa wild, has shown to increase the cleavage of caspase-3, -8 and -9 in hl-60 aml cells .
additionally, the elevation of erk1/2, jnk and cytochrome c release was observed in capillin treated hl-60 cells . cucurbitacin e elevates the expression level of bax while downregulating xiap, survivin and mcl-1, indicating that cucurbitacin e has a role in cucurbitacin e-induced apoptosis in hl-60 cells . shikonin from lithospermum erythrorhizon up-regulated the generation of ros and the cleavage of caspase-3 in hl-60 cells . conversely, the expression of the apoptotic genes such as bax, c-caspase-3, and 9 were upregulated. further studies with regards to the synergistic effects of conventional drugs with natural products for aml treatment are strongly required. we categorized the natural products and their mechanisms of actions based on a phytomedicinal classification.
the american cancer society offers programs and services to help you during and after cancer treatment. at the american cancer society, we’re on a mission to free the world from cancer. your options may be affected by the aml subtype, as well as certain other prognostic factors, as well as your age and overall state of health. it’s important to discuss all of your treatment options and their goals and possible side effects, with your treatment team to help make the decision that best fits your needs.
a second opinion can give you more information and help you feel more confident about the treatment plan you choose. you may hear about alternative or complementary methods that your doctor hasn’t mentioned to treat your cancer or relieve symptoms. communicating with your cancer care team is important so you understand your diagnosis, what treatment is recommended, and ways to maintain or improve your quality of life. remember that even if you choose not to treat the cancer, you can still get supportive care to help with pain or other symptoms. don’t hesitate to ask your cancer care team any questions you may have about your treatment options.
some potent compounds for treating aml include aromatic tumerone and fucoxanthin in carotenoids and asterosaponin in organosulfur compounds. the nhi recognizes 3 major modalities of cm treatment: (1) chinese herbal medicine (chm) products, which come in the form of single-herb or multiherb products; you may hear about alternative or complementary methods that your doctor hasn’t mentioned to treat your cancer or relieve symptoms. these methods can include, related conditions, related conditions.
some research suggests that acupuncture may improve symptoms of aml. for example, a 2019 study of 60 people with aml who had stem cell transplants found that those who undergo acupuncture require less pain relief medication than those who did fake acupuncture. two pd-1 inhibitors, nivolumab (opdivo, bristol myers squibb) and pembrolizumab (keytruda, merck), and two anti–pd-l1 monoclonal antibodies ( acupuncture may alleviate symptoms. acupuncture may help to enhance immune function, normalize digestion, and address disease conditions. for the prognosis for older patients with acute myeloid leukemia (aml) is poor: very few achieve remission and for those that don’t the option, .
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