the first clinical study on the effect of herbal medicine was published in 1995; moreover, most studies were conducted in china. the underlying pathogenesis of motor neuron degeneration in als is protein aggregation and glutamate-induced excitatory toxicity. this study aimed to analyze studies on herbal medicine treatment for als to assess the treatment effects, evidence regarding the effects, and the type of future studies required for further evidence. in cases of disagreement, the studies were reviewed together to reach a consensus. demographic characteristics of the study participants included sex and age. all the studies were conducted in china and south korea. no studies reported on the safety and side effects. the mean disease duration was 5, 1.67, and 4.75 years in the studies by liang , byun et al. none of the studies reported safety and side effects. the mean age of the participants and disease duration was 62.3 years and 2.1 years, respectively. the mean age of participants was 51.5, 50, 53.39, 55.65, and 55.9 years in the studies by liu , kim et al.
, 18 months in the studies by sun  and zhao , 43.41 months in the studies by kim et al. in the studies by kim et al. the authors classified and analyzed clinical studies on herbal medicine treatment for als based on the treatment method.  reviewed 21 related studies to summarize the therapeutic effects of oriental medicine and tkm in patients with als.  analyzed the literature to summarize the characteristics of tcm and other drugs used for als prevention and treatment. the included studies were conducted in china and south korea, with over 70% of the studies being conducted in china. contrastingly, in south korea, treatment was selected on an individual basis to treat the main and secondary clinical symptoms. the progression rate of als (δfs) is a quantitative index used for assessing disease progression in patients.  reported two cases of diarrhea and nausea in the experimental group. both studies used placebo as a control treatment, and alsfrs-r scores, one of the most standard evaluation tools, were used to evaluate the effects of interventions on the progression of als. future studies with detailed designs could yield evidence regarding the effects of herbal medicine treatment for als and develop better treatments for patients with als.
given the severity of their illness and lack of effective disease modifying agents, it is not surprising that most patients with als consider trying complementary and alternative therapies. evidence supporting a survival benefit related to energy balance in als patients has been collected primarily from population studies that include assessment of bmi and malnutrition. dysphagia is present in 45% of patients with bulbar onset disease at diagnosis, and approximately 81% of all als patients will experience dysphagia as a symptom of als (23). in a recent clinical trial, comparing the potential of high calorie diets enriched with either fat or carbohydrates to restore weight in 24 individuals with als, both strategies were reported as safe and effective after 12 weeks of treatment (29). in the setting of a terminal disease without ample choices for disease-modifying therapies, these patients assert their autonomy and report that they self-medicate with dietary supplements to improve general wellbeing and slow disease progression (3). below is a select list of supplements, most with antioxidant properties, that have been proposed as potentially beneficial for the als patient. supporting biologic plausibility for catechins in the treatment of als, in vitro studies revealed that epicatichin-3-gallate reduced hyperexcitability in sod1 motor neurons by interfering with glutamate hyperexcitability, and had a rescue effect in motor neurons exposed to h2o2 (44). idebenone continues to be available online through neutraceutical providers, and is included as one of the key supplements in the deanna protocol. resveratrol is a polyphenol found in the skin of grapes, blueberries, raspberries and mulberries. the authors hypothesized that homocysteine may be a biomarker of als and may be involved in the pathophysiology (73). a small clinical study showed that patients with als tended to have low vitamin d levels and that oral vitamin d supplementation with 2000 i.u./day was safe and may be of benefit (86).
there are a number of animal studies suggest that the endocannabinoid system is implicated in the pathophysiology of als (93–99). the cannabinoids themselves are all lipophilic and not soluble in water. in addition to pain and spasticity, there are other pharmacological effects of cannabis that may be useful for als patients. cannabinoids in the form of an aerosol in inhaled smoke or vapors are absorbed and delivered to the brain and circulation rapidly, as expected of a highly lipid-soluble drug. finally the cannabinoids may also be made in to a liniment and absorbed through the skin, although this is the least efficient mode of delivery. there is only 1 published trial of acupuncture in patients with als (173). chelation therapy is a medical procedure in which a chelating agent is administered to the patient with the objective of removing a specific heavy metal from the body. in fact, there is evidence to the contrary. there are no trials on the effect of energy healing in als patients. this model ignores the fact that patients are different in terms of how they want their information presented (208). inputs on alternative als therapies come from patients and families, either via face to face visits with clinicians that are part of the group, or via email or twitter (@alsuntangled).
this study aimed to analyze and summarize the existing evidence regarding herbal medicine treatments for amyotrophic lateral sclerosis (als). some of the most commonly considered alternative therapies include special diets, nutritional supplements, cannabis, acupuncture, chelation and our study demonstrated that almost half of patients surveyed utilized herbals supplements, and two thirds of als study subjects took vitamins., cure for als found, cure for als found, als recovery stories, supplements for als reversal, herbal medicine als module.
riluzole and edaravone have been used for the treatment of patients with als, but they do not offer complete cure. therefore, it is necessary to on the less extreme end, many people with. als use readily available over-the-counter treatments, nutrients, herbal supplements, and natural therapies that they generally, acupuncture is protective, or improves the phenotypes (cognitive function in ad, tremor in pd) through brain functional activity in neurodegenerative, curcumin als reversal, als reversal diet, lysine als, als antioxidants.
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