there is no systematic evaluation on the clinical efficacy of ra and ras in patients with ipf. there is no systematic evaluation report on the clinical efficacy of ra and ras as the main components of herbal medicine in the treatment of ipf. using the jadad rating scale (higgins et al., 2011) and the cochrane reviewer’s handbook for guidelines, the quality and risk of bias of included studies were assessed (higgins et al., 2011). one rct (peng, 2019) used the prescription of tcm only included ra and ras and other rcts used the prescription of tcm included ra and ras as the main components. the two studies (zhao et al., 2016; guo et al., 2019) that compared fvc included a total of 250 participants, 125 and 125 in experimental group and control group, respectively. the two studies (sun, 2005; chen et al., 2012) that compared tlc% pred included a total of 88 participants, 45 and 43 in experimental group and control group, respectively. the four studies (sun et al., 2008; wu et al., 2012; guo et al., 2019; peng, 2019) that compared total score of sgrq score included a total of 276 participants, 139 and 137 in experimental group and control group, respectively. the three studies (sun et al., 2008; wu et al., 2012; guo et al., 2019) that compared symptoms score of sgrq score included a total of 226 participants, 114 and 112 in experimental group and control group, respectively. the seven studies (sun, 2005; wei and qiang, 2007; yang, 2010; meng et al., 2016; ma, 2018; guo et al., 2019; peng, 2019) that compared incidence of adverse reactions included a total of 474 participants, 247 and 227 in experimental group and control group, respectively. in this study, the rcts of ra and ras in the treatment of ipf were systematically evaluated and meta-analysis was carried out. incidence of adverse reactions was statistically significantly lower in experimental group than control group, which suggest that the clinical application of ra and ras in the treatment of ipf is safe. to sum up, ra and ras are effective and safe in the treatment of ipf, which is beneficial to pulmonary function and exercise tolerance of these patients. real-life comparison of pirfenidone and nintedanib in patients with idiopathic pulmonary fibrosis: a 24-month assessment. effect of huangqi taohong decoction combined with prednisone on idiopathic pulmonary fibrosis caused by qi deficiency and blood stasis and its effect on the expression of igf-i and igfbp-4 in bronchoalveolar lavage fluid.
clinical observation on the treatment of idiopathic pulmonary interstitial fibrosis by kangxian shufei granule. effect of qizhu kangxian granule on pulmonary function and quality of life in patients with idiopathic pulmonary fibrosis. idiopathic pulmonary fibrosis: the current status of its epidemiology, diagnosis, and treatment in china. global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review. analysis on the value of yiqi huotan zhuyu method in treating idiopathic pulmonary fibrosis of qi deficiency and blood stasis type. influence of the pair drugs of astragalus and angelica on the ipf living conditions and tissue repair related gene expression level in mice, glob. clinical analysis of traditional chinese compound nourishing yin and reinforcing qi in the treatment of pulmonary fibrosis. classification, hepatotoxic mechanisms, and targets of the risk ingredients in traditional chinese medicine-induced liver injury. care med. interference of tonifying qi, activating blood and dispersing accumulation on pulmonary fibrosis and the mechanism research. a preliminary study on the clinical observation and mechanism of qihong prescription in the treatment of idiopathic pulmonary fibrosis, beijing university of chinese medicine. effectiveness and safety of chinese medicine for idiopathic pulmonary fibrosis: a systematic review and meta-analysis. effects of feiwei granules in the treatment of idiopathic pulmonary fibrosis: a randomized and placebo-controlled trial. pharmacological mechanism of astragalus and angelica in the treatment of idiopathic pulmonary fibrosis based on network pharmacology. high dose n-acetylcysteine combined with traditional chinese medicine anti-fibrosis prescription in the treatment of idiopathic pulmonary fibrosis.
the changing landscape of ipf diagnosis and management present a number of issues that may be encountered including management of side effects related to antifibrotic therapy. however, with the introduction of anti-fibrotic agents including pirfenidone and most recently nintedanib there has been a dramatic field change in the management of ipf. fvc decline is the only reliable surrogate marker for mortality in ipf and is thus the primary end-point in clinical trials of treatments in ipf (8). this pathway is thought to be involved in the development of fibrosis and its inhibition leads to a reduction in pro-fibrotic mediators (15). both pirfenidone and nintedanib have similar effects on lung function with pirfenidone showing a mortality benefit in pooled data. the advantage of this is that dose reductions and re-titrations can be employed to manage side effects.
however, despite diarrhoea being the most commonly reported adverse event with nintedanib, less than 5% of patients with diarrhoea discontinued treatment in both inpulsis-1 and inpulsis-2. following a diagnosis of ipf best supportive care should be offered in parallel to antifibrotic medication to help patients and their families maintain their quality of life and learn how to live with the complexities of the disease. the underlying mechanism of cough in ipf is complex and likely multi-factorial (35). the use of pirfenidone has been shown to have a possible beneficial effect on cough in a subgroup population of ipf patients (19). the progressive nature of ipf, with increasing shortness of breath and reduction in patient’s ability to complete daily activities can significantly impair emotional well-being. uk guidance suggests all patients and partners affected by ipf should have access to a specialist nurse through all phases of the disease (49). both drugs have significant but manageable side effect profiles and specialists managing patients with ipf need to take this into consideration when selecting the right drug for the right patient.
alternative treatments for pulmonary fibrosis. medicinal mushrooms, acupuncture, and meditation may offer relief. introduction: there are many clinical studies in the treatment of idiopathic pulmonary fibrosis (ipf) with herbal medicine including astragalus triple therapy with prednisolone, azathioprine and n-acetylcysteine (nac) became the treatment of choice following the publication of the, miracle cure for pulmonary fibrosis, miracle cure for pulmonary fibrosis, chinese herbal medicine for pulmonary fibrosis, latest treatment for pulmonary fibrosis, living 20 years with pulmonary fibrosis.
the following are some alternative and complementary therapies that may be useful for people coping with pulmonary fibrosis, (hong hua), and radix paeoniae rubra (chi shao) are the typical herbs that promote blood circulation for removing blood stasis. ophiopogonis two treatment modalities for ipf that the patient used show promise for future research: glycyrrhiza glabra (licorice root) and acupuncture. the medical, supplements for pulmonary fibrosis, pulmonary fibrosis cure diet, reversing idiopathic pulmonary fibrosis, mullein for pulmonary fibrosis, nebulizer for pulmonary fibrosis, lung fibrosis treatment in covid, metformin for pulmonary fibrosis, types of pulmonary fibrosis, dhea pulmonary fibrosis, lung scar removal. here are a some home remedies for pulmonary fibrosis:cod liver oil. cod liver oil contains fatty acids that can help with the smooth functioning of the body’s processes. stop smoking. baking soda. water. colloidal silver. citrus fruits. green leafy vegetables.
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