this article aims to provide an overview of the pharmacological effects of danggui in reducing the size of cerebral infarction and improving neurological deficit scores. moreover, the cerebral infarction size is larger in a model of enos mutant mice with middle cerebral artery occlusion (mcao) . the etiology of atherosclerosis and stroke is related to inflammation and genetic factors.  found that the levels of tgb-β reduced and those of bfgf increased in human umbilical vein endothelial cells damaged by hyperlipidemic serum.
both danggui and sodium ferulate inhibit the formation of atherosclerosis because danggui reduces the tg and lipid peroxidation levels or increases no production, or both. reduces the size of cerebral infarction and neurological deficit scores and inhibits icam-1 and nf-κb expression in transient mcao rats . enhanced the expression of gabab1 in the reperfusion period (three and 24 hours after ischemia) in rats . danggui reduces the size of cerebral infraction and improves neurological deficit scores. danggui may be useful in treating the cerebral infarction type of stroke.
these results suggested that the modulation of the blood system was involved in the anti-depression effect of as. on the other hand, anemia directly affects brain function and can result in cognitive impairment (pickett et al., 1999), which contributes to the development of depression. the shared metabolites and pathways regulated in both the depression and anemia model, through the administration of as, were further analyzed. animals were given the calculated amounts of fractions with the administration of a volume of 10 ml/kg (rat body weight), the rats in the control and model groups were given water. every rat was placed into the center of the box and observed for 5 min. the fst apparatus was a cylindrical container (50 cm in height and 20 cm in diameter) filled with water at 25 ± 2°c to a depth of 30 cm. the total proteins of the liver were extracted, and the concentrations were measured by a bca procedure. the treatment group of as and vlf resulted in a significant increase in sucrose preference compared with the cums group, indicating a reduction of anhedonia. on the contrary, the level of po2 and so2 was significantly increased after the treatment with as and vlf. pls-da was future performed to investigate the regulatory effect of as and vlf. significantly differential metabolites were screened according to the vip values of s-plots (>1.0) and t-tests (p < 0.05). to investigate the linkage between the effect of anti-depression and modulating the blood system of as, the disturbed metabolites regulated by as in anemia were mined according to previous literature. the level of pdk-1 and ldha was significantly elevated in the liver of rats in the cums group compared with that in the control group, suggesting that energy metabolism was disrupted after the cums procedure. angiogenesis and neurogenesis is interdependent in the neurogenic/neurotrophic theory of depression. therefore, the level of citrate was higher in the as group than that in the vlf group. in the current study, we demonstrated that sphinganine and phytosphingosine were significantly increased in the cums group, while sphinganine was significantly decreased after the administration of as.
xl assisted in the testing and analysis of data. laboratory diagnosis of anemia: are the old and new red cell parameters useful in classification and treatment, how? anemia and thrombocytopenia in acute and chronic renal failure. role of vascular endothelial growth factor in adult hippocampal neurogenesis: implications for the pathophysiology and treatment of depression. a novel approach using metabolomics coupled with hematological and biochemical parameters to explain the enriching-blood effect and mechanism of unprocessed angelica sinensis and its 4 kinds of processed products. prolyl hydroxylase inhibitors: a breakthrough in the therapy of anemia associated with chronic diseases. stress polycythemia and organ choice(on the organ choice in psychosomatic disorders). is there a role for anxiety and depression? anemia is associated with disability and decreased physical performance and muscle strength in the elderly. rapid antidepressant effects of yueju: a new look at the function and mechanism of an old herbal medicine. differential diagnosis of microcytic anemia: the role of microcytic and hypochromic erythrocytes. regulation of the kynurenine metabolism pathway by xiaoyao san and the underlying effect in the hippocampus of the depressed rat. anti-depression effects of danggui-shaoyao-san, a fixed combination of traditional chinese medicine, on depression model in mice and rats. ferulic acid exerts antidepressant-like effect in the tail suspension test in mice: evidence for the involvement of the serotonergic system. antidepressant-like effects of the fractions of xiaoyaosan on rat model of chronic unpredictable mild stress. the use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice.
angelica sinensis, commonly known as dong quai or female ginseng, is a herb belonging to the family apiaceae, indigenous to china. angelica sinensis grows in cool high altitude mountains in east asia. radix angelica sinensis, the dried root of angelica sinensis (danggui), is a herb used in chinese medicine to enrich blood, promote blood circulation and angelica sinensis is a traditional chinese herbal medicine with a gentle warming action. it is believed to nourish the blood, restore the body’s natural balance angelicae sinensis radix (as), a well-known herb in traditional chinese medicine (tcm), has been wildly used for replenishing the blood and, angelica sinensis benefits, angelica sinensis benefits, angelicae dahuricae radix, angelica sinensis common name.
angelica sinensis, commonly known as dong quai or female ginseng, is a herb belonging to the family apiaceae, indigenous to china. angelica sinensis grows dong quai (angelica sinensis) root has been used for more than one thousand years as a spice, tonic, and medicine in china, korea, and japan. dong quai (angelica sinensis) is a plant that has been used for a variety of conditions, with little evidence. it may be unsafe when too much is consumed., .
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