essential oils of chamomile are used extensively in cosmetics and aromatherapy. chamomile is one of the oldest, most widely used and well documented medicinal plants in the world and has been recommended for a variety of healing applications (7). chamomile is known to be used in various forms of its preparations. chamomile in the form of an aqueous extract has been frequently used as a mild sedative to calm nerves and reduce anxiety, to treat hysteria, nightmares, insomnia and other sleep problems (33). in another study (47), on twelve patients with cardiac disease who underwent cardiac catheterization, hemodynamic measurements obtained prior to and 30 minutes after the oral ingestion of chamomile tea exhibited a small but significant increase in the mean brachial artery pressure. the manzana type of chamomile is rich in active ingredients and does not exhibit chamomile-related allergenic potential.
further research is needed to evaluate the usefulness of topical chamomile in managing eczema. patients were entered into the study at the time of their first cycle of 5-fu-based chemotherapy and were randomized to receive a chamomile or placebo mouthwash thrice daily for 14 days. to prevent bone loss that occurs with increasing age, chamomile extract was evaluated for its ability to stimulate the differentiation and mineralization of osteoblastic cells. additional studies are required to evaluate the usefulness of chamomile in managing diabetes. the efficacy of topical use of chamomile to enhance wound healing was evaluated in a double-blind trial on 14 patients who underwent dermabrasion of tattoos. a relatively low percentage of people are sensitive to chamomile and develop allergic reactions (87). it is advisable that the discriminate and proper use of chamomile preparations could be safe and provide therapeutic benefits however the indiscriminate or improper use can be unsafe and harmful.
finally, data on flavonoids from the main public databases are gathered to highlight the apigenin’s key role in dietary assessment and in the evaluation of a formulated diet, to determine exposure and to investigate its health effects in vivo. apigenin (4′,5,7-trihydroxyflavone) (figure 2) is one of the most widespread flavonoids in plants and formally belongs to the flavone sub-class. flavonoids, in general, are widely known for their antioxidant properties and a huge number of reports in the literature have reported the antioxidant properties of apigenin [34]. this may limit the use of apigenin in in vivo studies. [61] summarized the multiple therapeutic functions of apigenin by in vitro and in vivo systems. panda and kar [110] also showed that alloxan-induced elevation in serum cholesterol was also reverted by the administration of apigenin, while ren et al. additionally, it was shown that apigenin caused restoration of the erk/creb/bdnf pathway, involved in memory and typically affected in alzheimer’s disease. the results suggested an antioxidant role of apigenin in response to the injury.
accordingly, apigenin reduced the latency in the onset of picrotoxin-induced convulsions. in the study conducted by li and others [101], the effects of apigenin on lipopolysaccharide (lps)-induced depressive-like behavior in mice model were examined. the authors concluded that chamomile treatment could provide modest benefits in terms of daytime functioning and mixed benefits in terms of sleep diary measures. the therapeutic antitumor effects of apigenin were evaluated using an in vivo mouse model by chuang et al. torkin and co-workers [88] investigated the effect of apigenin in doses of 25 mg/kg as an inhibitory agent of neuroblastoma tumor in mice. apigenin activity was a subject of investigation in the treatment of prostate cancer conducted by shukla and others [89]. sui and co-workers [139] tested the apigenin effect on the expression of angiotensin-converting enzyme 2 (ace2) in the kidneys of spontaneously hypertensive rats. the usda database was developed in 2004 and has included flavonoids in subsequent versions [151], based on a compilation of data from the literature. there is a need to establish new and adequate cellular and animal models, which may, in turn, allow the design of more efficient and prevention-targeted clinical studies using apigenin and/or its derivatives as candidates for therapeutic drugs in the near future.
chamomile is useful to calm frayed nerves, to treat various digestive disorders, to relieve muscle spasms, and to treat a range of skin conditions and mild optimum chamomile extracts contain about 50 percent alcohol. normally standardized extracts contain 1.2% of apigenin which is one of the most effective chamomile (matricaria chamomilla) extract, considered a rich source of apigenin, was investigated as a natural agent for behavioral recovery, apigenin supplement, apigenin supplement, apigenin supplement for sleep, best apigenin supplement, apigenin dosage for cancer.
apigenin can be found in chamomile, which is normally drunk as a tea. it is obtained from the dried flowers of matricaria chamomilla, an annual herb native to one of the bioflavonoids, apigenin appears to be catered towards reducing anxiety and causing sedation. found in chamomile tea, chamomile extract has a long list of potential health benefits. to start with it is a natural source of apigenin. it contains high levels of antioxidants and, apigenin 500mg, apigenin amazon.
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