inflammation is a part of the immune response that can prevent infection through production of pro-inflammatory cytokines and generation of inflammatory mediators in response to microbial products. traditional chinese medicine (tcm) has been used in china over thousands of years for the prevention and treatment of various diseases. this review tries to summarize the effect of hcchs which have shown anti-inflammatory and antimicrobial activities and their mechanisms of action. baicalensis has antibacterial effect against helicobacter pylori as well as inhibits the growth of escherichia coli b, coagulase-negative staphylococci, and saccharomyces cerevisiae. it is a widely used herb in china for the treatment of infection by exopathogenic wind-heat or epidemic febrile diseases.
the leaves of isatidis folium are traditionally used for the treatment of sore throat, redness of skin, and as an antipyretic. [13,14,19] the dry root of isatidis radix has many pharmacological activities such as antibiotic, anti-diabetic, and immune-stimulating effects and is used to treat encephalitis b and viral infections. [13,14] the root of pulsatilla radix has anti-inflammatory, antiparasitic, and antimicrobial action.  houttuynia cordata is one of the two species in the genus houttuynia and belongs to the family saururaceae. collectively, all the above mechanisms are likely to be important for the anti-inflammatory and antimicrobial activity of hcchs.
moreover 43% of âqing re yaoâ herbs affect 3 or more mechanisms while none of the âbu yi yaoâ have this poly-mechanism quality. in order to assess whether chinese herbs that were used frequently in clinics have anti-inflammatory activity or immunity modulatory activity, the impact of 226 tcm herbs, (54 of which are classified as âqing re yaoâ), on the expression of different pathway genes and luciferase at various concentrations (28, 83, 250, 750âî¼g/ml) was examined on different signal pathways or up to 4âmg/ml herb on inos and cox2 enz activity. for herbs with no activity against inflammatory activity, we tested different batches of the same herbs in order to ensure that its lack of activity was not due to being inert. (a) percentage of âqing re yaoâ and âbu yi yaoâ in affecting on the inflammatory cytokine or glucocorticoid signaling pathway and cox2, inos enzyme activity. in this study we observed the impact of those herbs on stat3 and gas downstream target genes. in the figsâ 3 and 4, the effects of âqing re yaoâ on stat3 and gas gene expression are shown. on a finer level, the different classes making up âqing re yaoâ may be linked to the different kinds of inflammation found in different organs. it should be noted that âqing re yaoâ is not the only category of herbs exhibiting anti-inflammation activity. in other words, the proportion of multiple anti-inflammatory activity in âqing re yaoâ is significantly higher than any of other herb categories and unique.
in this first study of an entire category of chinese medicine herbs, we found that the majority of the âqing re yaoâ herbs demonstrate anti-inflammatory activity and that each herb uses a combination of multiple mechanisms for targeting inflammation. the data is stored in the database of our laboratory and is accessible to the public upon request. inhibition was cut defined as more than 50% inhibition; stimulation was defined as more than 3 times stimulated vs the baseline of stimulator activity at concentration of herbs under 750ââµg/ml in luciferase reporter signaling assay or under 4âmg/ml in enzyme assay. hirano, t., ishihara, k. & hibi, m. roles of stat3 in mediating the cell growth, differentiation and survivial signals relayed trough the il-6 family of cytokine receptors. & baldwin, a. s. jr. interleukin-10 signaling blocks inhibitor of kappab kinase activity and nuclear factor kappab dna binding. & levy, r. m. a medicinal extract of scutellaria baicalensis and acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. zhou, l. & zhou, b. y. influence of baicalin on tnf-alpha and soluble intercellular adhesion molecule-1 in rats infected with pneumocystis carinii. influence of paeonia lactiflora roots extract on camp-phosphodiesterase activity and related anti-inflammatory action. did cell lines construct and wrote the manuscript. majority of chinese medicine herb category âqing re yaoâ have multiple mechanisms of anti-inflammatory activity.
for example, peoria lactiflora (herb 55) is used to treat painful or inflammatory disorders in traditional chinese medicine. lycium barbarum ( among many of nature’s solutions, a few anti-inflammatory foods, which support your immune stem, include curcumin or turmeric, fennel, ginger, increase your use of bay leaf, cilantro, dill and other herbs like rosemary, thyme, and oregano, all of which have anti-internal heat properties, .
6-gingerol, 6-shogaol, andrograpanin, phylligenin, tectorigenin, rhein, baicalin, berberine, naringenin, cimiracemate a, ligustilide and schicantherin a are bioactive substances in medicinal plants that have been reported to decrease lps and/or ifn-u03b3-induced production of pro-inflammatory cytokines and mediators in twhf is an herbal remedy used in traditional chinese medicine for the treatment of swelling, inflammation and joint pain. the remedy comes the bi-qi capsule is a tcm formula approved by the chinese food and drug administration to treat rheumatoid arthritis (ra), cervical spondylosis, .
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