although ginger is generally considered to be safe (kaul and joshi 2001), the lack of a complete understanding of its mechanisms of action suggests caution in its therapeutic use (wilkinson 2000a). in the thirteenth and fourteenth centuries, the value of a pound of ginger was equivalent to the cost of a sheep. of the bioactive pungent components of jamaican ginger, including -, -, and -gingerols and -shogaol, -gingerol appears to be the most abundant pungent bioactive compound in most of the oleoresin samples studied (bailey-shaw et al. a method has been developed for the simultaneous quantification of -, -, and -gingerol and -shogaol in rat plasma in pharmacokinetic studies after oral administration of ginger oleoresin (wang et al. the presence of oxidative stress is associated with numerous diseases and a common mechanism often put forth to explain the actions and health benefits of ginger is associated with its antioxidant properties (aeschbach et al. ginger consumption has also been reported to decrease lipid peroxidation and normalize the activities of superoxide dismutase and catalase, as well as gsh and glutathione peroxidase, glutathione reductase, and glutathione-s-transferase, in rats (ahmed et al. evidence does seem to suggest that ginger and some of its components are effective antioxidants in vitro. more recently, the effectiveness of a crude ginger extract was compared with a fraction containing only gingerols and derivatives to inhibit joint swelling in the streptococcal cell wall-induced arthritis animal model of rheumatoid arthritis (funk et al. in humans, one study showed no difference between placebo and ginger in patients with osteoarthritis of the hip or knee (bliddal et al. this idea was supported by the results of a randomized, double-blind trial in which healthy volunteers reported that ginger effectively accelerated gastric emptying and stimulated antral contractions (wu et al. a follow-up study also indicated that 1 g of ginger might be effective in reducing the subjective severity of seasickness in naval cadets on the high seas (grontved et al. a systematic review of the results of other double-blind, randomized, controlled trials, uncontrolled trials, case reports, and observational studies indicated that ginger is superior to placebo and as effective as vitamin b6 in relieving the severity of nausea and vomiting, with no reported side effects or adverse effects on pregnancy (borrelli et al. however, the effectiveness of ginger in preventing postoperative nausea and vomiting has been disputed (visalyaputra et al. in contrast, at least one trial indicated that ginger was not effective in reducing the incidence of postoperative nausea and vomiting in patients undergoing gynecologic laparoscopy (eberhart et al.
because the cxcr4 mediates homing of tumor cells to specific organs that express its ligand, cxcl12, zerumbone was suggested as a potential suppressor of cancer metastasis and was effective in suppressing cxcr4 in a variety of cancers, including those of the pancreas, lung, kidney, and skin (sung et al. ginger extract and especially -gingerol were reported to effectively decrease proliferation of yyt colon cancer cells and the angiogenic potential of endothelial cell tubule formation in immortalized ms1 endothelial cells (brown et al. we previously investigated the effect of two structurally related compounds of the ginger family, -gingerol and -paradol, on egf-induced cell transformation and ap-1 activation (bode et al. further, -shogaol was reported to inhibit the growth of and induce apoptosis in colo 205 cells (pan et al. this idea is supported by data indicating that the reduction of uvb-induced expression and transactivation of cox-2 by -gingerol was associated with the suppression of iκbα phosphorylation (ser32) resulting in a decreased translocation of nf-κb from cytosol to nucleus in hacat cells (kim et al. this ginger derivative appeared to exert its effects by inhibition of proliferation, induction of apoptosis, and suppression of nf-κb and heme oxygenase expression in both colon and lung cancer tissues (kim et al. collectively, these findings indicate a crucial role of lta4h in cancer and also support the anticancer efficacy of -gingerol targeting of lta4h for the prevention of colorectal cancer (jeong et al. these findings were supported in a later study in which ginger was reported to have no effect on clotting status or the pharmacokinetics or pharmacodynamics of warfarin in healthy subjects (jiang, williams et al. in a comparison of gingerols and analogs with aspirin, ginger compounds were found to be less potent compared to aspirin in inhibiting arachidonic acid-induced platelet release and aggregation and cox activity (koo et al. components of ginger rhizomes are reported to contain potent compounds capable of suppressing allergic reactions and might be useful for the treatment and prevention of allergic diseases (chen et al. in a mouse model of th2-mediated pulmonary inflammation, an intraperitoneal injection of a ginger extract mainly comprised of gingerols markedly decreased the recruitment of eosinophils to the lungs in ovalbumin-sensitized mice and also suppressed the th2 cell-driven response to allergen (ahui et al. oral administration of a ginger extract (1000 mg/kg) was reported to be tolerated well by pregnant rats, and it exerted no adverse effects on the mothers or in the development of fetuses (weidner and sigwart 2001). the most common use of ginger is to alleviate the vomiting and nausea associated with pregnancy, chemotherapy, and some types of surgery. however, in spite of the lack of specific mechanistic information, use of ginger appears to be safe and its effects are mighty and amazing in its many applications.
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ginger has been used for thousands of years for the treatment of numerous ailments, such as colds, nausea, arthritis, migraines, and hypertension. the medicinal it’s used as a food flavoring and medicine. ginger contains chemicals that might reduce nausea and swelling. these chemicals seem to work in the stomach and people have used ginger in cooking and medicine since antiquity. it remains a popular home remedy for nausea, stomach pain, and other health issues., .
today, health care professionals may recommend ginger to help prevent or treat nausea and vomiting from motion sickness, pregnancy, and cancer chemotherapy. it is also used to treat mild stomach upset, to reduce pain of osteoarthritis, and may even be used in heart disease. health benefits of ginger nausea relief. encouraging stomach emptying can relieve the discomforts of nausea due to: bloating and gas. eating ginger can cut ginger has been used in alternative medicine as a possibly effective aid in treating nausea and vomiting after surgery, dizziness, menstrual ginger has been used in alternative medicine as a possibly effective aid in treating nausea and vomiting after surgery, dizziness, menstrual, . 11 proven health benefits of gingercontains gingerol, which has powerful medicinal properties. can treat many forms of nausea, especially morning sickness. may help with weight loss. can help with osteoarthritis. may drastically lower blood sugars and improve heart disease risk factors. can help treat chronic indigestion.
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