can relieve the pathological status in cellular and animal models of dkd. over the last decade, promising advancements have been made in the mechanisms and clinical outcomes of panax ginseng c.a.mey. on kidney protection in the kidney filtration barrier and innate renal cells. the disappearance of podocyte foot processes is a sign of podocyte damage and proteinuric kidney disease, accompanied by changes in podocyte protein expression and reorganization of the actin cytoskeleton (fan et al., 2021). more and more evidences are suggesting the abnormal growth of mcs is an early event in various glomerular diseases (yoon et al., 2020; wan et al., 2021). and the expression of proliferating cell nuclear antigen (pcna) protein and pcna mrna were upregulated (yang et al., 2015). plays an important role in the improvement of hypertension, hyperglycaemia and lipid metabolism disorders. in the renal artery ischemia of white rabbits, rb1 can downregulate the expression of bcl-2 and bax to inhibit apoptosis and reduce kidney damage (zhu et al., 2009). however, fewer data are available in the field of panax ginseng c.a.mey. the results agreed with the findings of ckd patients from peng and guo (2010) and xu et al. therefore, evaluating the composite of renal outcomes in clinical trials is a future direction for researchers. although the efficacy and safety of panax ginseng c.a.mey. all claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. incretin drugs in diabetic kidney disease: biological mechanisms and clinical evidence. a literature update elucidating production of panax ginsenosides with a special focus on strategies enriching the anti-neoplastic minor ginsenosides in ginseng preparations. recent advances on ginseng research in china. effects of processing method on the pharmacokinetics and tissue distribution of orally administered ginseng. diagnosis and management of type 2 diabetic kidney disease. ginsenosides for the treatment of metabolic syndrome and cardiovascular diseases: pharmacology and mechanisms. the efficacy of ginseng-related therapies in type 2 diabetes mellitus: an updated systematic review and meta-analysis. oral absorption of ginsenoside rb1 using in vitro and in vivo models. novel ginsenoside derivative 20(s)-rh2e2 suppresses tumor growth and metastasis in vivo and in vitro via intervention of cancer cell energy metabolism. enhancement of oral bioavailability and immune response of ginsenoside rh2 by co-administration with piperine.
bioavailability of ginsenosides from white and red ginsengs in the simulated digestion model. the role of inflammasome-dependent and inflammasome-independent nlrp3 in the kidney. comparative study on effect of panax notoginseng and ticlid in treating early diabetic nephropathy. pharmacokinetics and efficiency of brain targeting of ginsenosides rg1 and rb1 given as nao-qing microemulsion. chicoric acid ameliorate inflammation and oxidative stress in lipopolysaccharide and d-galactosamine induced acute liver injury. absorption and disposition of ginsenosides after oral administration of panax notoginseng extract to rats. doi:10.1016/j.transproceed.2014.10.047 liu, l., vollmer, m. k., ahmad, a. s., fernandez, v. m., kim, h., and doré, s. (2019). unraveling the role of inflammation in the pathogenesis of diabetic kidney disease. effect of protopanaxadiol derivatives in high glucose-induced fibronectin expression in primary cultured rat mesangial cells: role of mitogen-activated protein kinases and akt. anti-ageing active ingredients from herbs and nutraceuticals used in traditional chinese medicine: pharmacological mechanisms and implications for drug discovery. aki in the icu: definition, epidemiology, risk stratification, and outcomes. sun, w., feng, l. y., zhao, z. j., liu, t. h., and yang, m. j. protective effect of ginsenoside rb1 against intestinal ischemia-reperfusion induced acute renal injury in mice. early detection of ckd: implications for low-income, middle-income, and high-income countries. recent advances in ginseng as cancer therapeutics: a functional and mechanistic overview. influence of ginsenoside rg1, a panaxatriol saponin from panax notoginseng, on renal fibrosis in rats with unilateral ureteral obstruction. self-micelle formation and the incorporation of lipid in the formulation affect the intestinal absorption of panax notoginseng. selective effects of ginseng pectins on galectin-3-mediated t cell activation and apoptosis. a study of ginsenoside-rd in a renal ischemia-reperfusion model. effect of ginsenoside-rg1 and rb1 on the kidney and renal expression of mcp-1 mrna and protein in rat model with diabetic nephropathy. effects of ginsenoside rg1 on glomerular mesangial cell inflammation induced by glycosylation end products and tgfβ/smad signaling pathway. effects of rb1 and rg1 on the expression of bcl-2, bax in apoptosis of hk-2 cells induced by the serum of kidney ischemia/reperfusion. the use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice.
we investigated the effect of rge on gentamicin (gm)-induced apoptosis and oxidative stress in cultured renal tubular cells and animal model of gm-induced aki. rge was manufactured from the roots of a fresh panax ginseng c.a. after exposure of nrk-52e cells to gm for 48âh, cell suspensions were prepared by treating cells with trypsin/edta mixture in dmem. numbers in parenthesis refer to the numbers of rats killed on day 3 (d3) and day 10 (d10). differences in parameters at each time point and the concentration of gm or rge were compared by paired t-test and one-way anova. effect of rge on gm-induced changes in cell proliferation and cytotoxicity in renal tubular cells. rge significantly ameliorated gm-induced apoptosis of nrk-52e cells (figure 5a and b). this finding suggests that the effect of rge on gm-induced changes in renal tubular cells is not related to the interference in cellular uptake of gm. these findings suggested the role of ros generation via both nox activation and mitochondrial dysfunction in gm-induced apoptosis of renal tubular cells. effect of rge on proteinuria, renal function, and tubular necrosis in gm-induced aki.
this antioxidant effect of red ginseng was associated with the protection of renal tubular cells from apoptosis that resulted in a significant amelioration of gm-induced aki. the beneficial effect of rge on gm-induced apoptosis seems to be mediated by the antioxidant effect of rge as altered expressions of apoptosis-related proteins were preceded by ros production, and antioxidant treatment blocked the changes in these (figure 9). in our in vitro experiment, 100âî¼g/ml was a minimum concentration for the protective effect of rge on gm-treated renal tubular cells. reduction of renal blood flow and proximal bicarbonate reabsorption in rats by gentamicin. protective effect of korean red ginseng extract on cisplatin ototoxicity in hei-oc1 auditory cells. kallikrein/kinin protects against gentamicin-induced nephrotoxicity by inhibition of inflammation and apoptosis. beneficial effects of a combination of korean red ginseng and highly active antiretroviral therapy in human immunodeficiency virus type 1-infected patients. effects of korean red ginseng extract on acute renal failure induced by gentamicin and pharmacokinetic changes by metformin in rats. bcl-2-family proteins and the role of mitochondria in apoptosis. cardioprotective effects of 20(s)-ginsenoside rh2 against doxorubicin-induced cardiotoxicity in vitro and in vivo. protective effect of diallyl sulfide on oxidative stress and nephrotoxicity induced by gentamicin in rats.
du et al. suggested that panax ginseng . administration could protect kidney function via enhancing sirt1 and suppressing inflammation in many herbal supplements can interact with prescription drugs. a few examples are st. johns wort, echinacea, ginkgo, garlic, ginseng, ginger, and blue cohosh. if ginsenoside protected the kidneys from cisplatin-induced renal injury via an amelioration of oxidative stress and an inhibition of dna, benefits of ginseng for kidneys, benefits of ginseng for kidneys, is ginseng good for kidney stones, what supplements are bad for kidneys, what tea is good for kidney disease.
results of clinical research studies demonstrate that panax ginseng can help adjust blood pressure and reduce blood sugar and may be advantageous in the treatment of tuberculosis and kidney damage in people with diabetes. the heat-processing method to strengthen the efficacy of p. 1 ginseng is one of the most widely prescribed and intensively studied herbal medicines. several studies have indicated benefits of ginseng in the treatment of renal damage2,3 and hepatotoxicity. 4 however, acute kidney injury as an adverse effect has not been reported. (rxwiki news) supplements containing certain herbs, like ginseng, may be potentially harmful for people at risk for kidney disease. the food and drug administration (fda) is advising consumers not to purchase or use ginseng for reinforcing kidney, a product promoted and ginseng did not affect serum cystatin c level. overall, long-term ginseng use had no effect on 24-hour bp and renal function in hypertensive, what herbs are bad for kidneys, ashwagandha for kidney patients.
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