this review highlights the effective treatment choices and candidate compounds for patients, practitioners, and researchers in the field of traditional chinese medicine. importantly, we found a considerable amount of evidence-based research for most of the chfs we examined, meaning the results can be used to guide clinical practice and research in related fields. it can be used to treat the syndrome of liver-chi stagnation (manifesting as pain in the lateral thorax, pressure in the chest, and tendency to sigh), as well as depression or irritability, belching, abdominal fullness and distention, white fur on the tongue, or a “wiry” pulse. the capsule was superior to placebo in terms of response and remission rates, and mean changes from baseline in the ham-d and tcm-syndrome scales. in a learned helplessness to inescapable electric shock model of depression in mice, wuling capsules showed antidepressant effects across multiple behavioral tests, including the shuttle-box test, novelty-suppressed feeding, and the fst. however, blockade of the pka–creb pathway reversed the increase in bdnf gene expression and the antidepressant effects of yueju but not ketamine. the relationship can be likened to a game of chess.notes: sovereign herbs play the most significant role in the treatment of the principal syndrome, like the king and queen in chess. there is evidence to support the effective and safe use of these nine chfs in the treatment of depression, with demonstrations of better efficacy than placebo and synergistically increased effects of conventional therapy. global variation in the prevalence and incidence of major depressive disorder: a systematic review of the epidemiological literature. the economic burden of adults with major depressive disorder in the united states (2005 and 2010). efficacy and tolerability of agomelatine in the treatment of depression. novel melatonin-based therapies: potential advances in the treatment of major depression. wang y, fan r, huang x. meta-analysis of the clinical effectiveness of traditional chinese medicine formula chaihu-shugan-san in depression. a systematic review on the efficacy, safety and types of chinese herbal medicine for depression. orthogonal array design for antidepressant compatibility of polysaccharides from banxia-houpu decoction, a traditional chinese herb prescription in the mouse models of depression. in vitro and in vivo antioxidant effects and the possible relationship between the antidepression efficacy of traditional chinese medicine formulation chaihu shugan san. effect of chaihu-shugan-san on the mrna expression of the 5-ht1a receptor and cellular proliferation in the hippocampus of epileptic rats with depression. the effect of chaihu-shugan-san and its components on the expression of erk5 in the hippocampus of depressed rats.
characterization of multiple constituents in kai-xin-san prescription and rat plasma after oral administration by liquid chromatography with quadrupole time-of-flight tandem mass spectrometry. kai-xin-san, a chinese herbal decoction containing ginseng radix et rhizoma, polygalae radix, acori tatarinowii rhizoma, and poria, stimulates the expression and secretion of neurotrophic factors in cultured astrocytes. a standardized chinese herbal decoction, kai-xin-san, restores decreased levels of neurotransmitters and neurotrophic factors in the brain of chronic stress-induced depressive rats. [a systematic review of therapeutic efficacy and safety of shugan jieyu capsules in the treatment of mild to moderate depression]. qiao y, wen j, song y, lu x, xiong z, li f. [study on in vitro and in vivo material base of sini san by uplc-pda-ms/ms]. screening of the antidepressant-like effect of the traditional chinese medicinal formula si-ni-san and their possible mechanism of action in mice. chen y, lu j, zhu m, luo l. [determination of multiple constituents in wuling capsules by hplc simultaneously]. the anti-depression effect of xylaria nigripes in patients with epilepsy: a multicenter randomized double-blind study. an investigation of the antidepressant action of xiaoyaosan in rats using ultra performance liquid chromatography-mass spectrometry combined with metabonomics. effects of the chinese traditional prescription xiaoyaosan decoction on chronic immobilization stress-induced changes in behavior and ultrastructure in rat hippocampus. cnp signal pathway up-regulated in rectum of depressed rats and the interventional effect of xiaoyaosan. [antidepressant effect of “yueju pills” ethanol extract and water extract in mice models of depression]. antidepressant effect of yueju-wan ethanol extract and its fractions in mice models of despair. a systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes. chinese herbal medicine for insomnia: a systematic review of randomized controlled trials. [internal relations between seven methods in prescription compatibility and toxicity and therapeutic effects of complex prescription]. the chinese medicine sini-san inhibits hbx-induced migration and invasiveness of human hepatocellular carcinoma cells. saki k, bahmani m, rafieian-kopaei m. the effect of most important medicinal plants on two important psychiatric disorders (anxiety and depression): a review. the opinions expressed in all articles published here are those of the specific author(s), and do not necessarily reflect the views of dove medical press ltd or any of its employees.
herbal medicine has been used for the treatment of depression in people’s republic of china for centuries, and is becoming more frequently used in western countries. importantly, we found a considerable amount of evidence-based research for most of the chfs we examined, meaning the results can be used to guide clinical practice and research in related fields. it can be used to treat the syndrome of liver-chi stagnation (manifesting as pain in the lateral thorax, pressure in the chest, and tendency to sigh), as well as depression or irritability, belching, abdominal fullness and distention, white fur on the tongue, or a “wiry” pulse. the capsule was superior to placebo in terms of response and remission rates, and mean changes from baseline in the ham-d and tcm-syndrome scales.
in a learned helplessness to inescapable electric shock model of depression in mice, wuling capsules showed antidepressant effects across multiple behavioral tests, including the shuttle-box test, novelty-suppressed feeding, and the fst. the present study is the first to describe these formulas in terms of source, tcm syndromes and effects, composition, chemical constituents, clinical trials, antidepressant mechanisms, indications, and side effects. there is evidence to support the effective and safe use of these nine chfs in the treatment of depression, with demonstrations of better efficacy than placebo and synergistically increased effects of conventional therapy. this research will benefit patients, practitioners, and researchers in the field of tcm. notes: sovereign herbs play the most significant role in the treatment of the principal syndrome, like the king and queen in chess.
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