herbal treatment for adenomyosis

the primary outcomes will be relief in pain and uterine bleeding. this study will provide the latest analysis of the currently available evidence for the efficacy of the adjuvant therapy of chm for the treatment of am. a systematic review evaluated the clinical efficacy and safety of sanjiezhentong capsules combined with levonorgestrel intrauterine system in the treatment of am. the present systematic review aims to evaluate the effectiveness and safety of chm combined with lng-ius for am. we will review the reference lists of relevant rcts and meta-analyses for possible eligible studies.




the revman 5.3 software will be used for quantitative data synthesis and data analysis. we will synthesize and analyze clinical data according to the level of i2 value. in addition, the impact of sample size and missing data will be taken into account. the review will synthesize the latest clinical research and evaluate the add-on effect of chm to lng-ius. all authors have read and approved the manuscript.

the effects of sgd, paeoniflorin, and liquiritin on the production of pge2 and pgf2α were assayed using elisa. the results of this study provide possible mechanisms for the bioactivity of sgd for treating adenomyosis and contribute to the ethnopharmacological knowledge about this prescription. with slight modifications [19], extract solutions of two single herbs and sgd were prepared in the following procedure. the lower passage number (three to six) of cells was used for experiments to avoid changes in phenotype and gene expression. isolated cells were first placed in 96-well microtiter plates at a density of 5 × 104 cells per well and cultivated in 100 μl of the dmem containing 10% fbs. the concentrations of pge2 and pgf2α in the culture supernatant were determined by elisa kits according to the manufacturer’s protocol.

meanwhile, the activity of sgd in decreasing pge2 and pgf2α production might be partly ascribable to paeoniflorin. in this study, we provide evidence that sgd and its active ingredients, paeoniflorin and liquiritin, have a beneficial effect in the treatment of adenomyosis. also reported that concentrations of pge2 and pgf2α in the culture medium of human myometrial biopsies were significantly decreased by the addition of sgd [42]. in the present study, uflc profiles of two single herbs and sgd were performed for quality control of sgd. meanwhile, sgd, paeoniflorin, and liquiritin significantly suppressed the expression of er-α mrna and otr mrna in human adenomyosis-derived cells. 81473715) and the special funds from central finance of china in support of the development of local colleges and university (educational finance grant no.

keywords: adenomyosis, chinese herbal medicine, levonorgestrel-releasing intrauterine system, protocol, systematic review. background. shaoyao-gancao decoction (sgd), a well-known traditional chinese medicine prescription, has been widely used to treat adenomyosis, dysmenorrhea, curcumin (a constituent of turmeric) lightens periods and helps lower pain and inflammation. zinc helps reduce pain and inflammation., .

this blend combines astringent herbs, uterine tonics and nutrients to support normal menstrual flow. it combines these herbs: ginger root, hormonal birth control. pills that have a combination of estrogen and progestin or patches or rings that have this combination are method 2. method 2 of 5: using natural and herbal treatments ; 1. take a magnesium supplement to help manage pms symptoms. ; 2. consume ginger extract or tea to, .

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