the epub format is best viewed in the ibooks reader. diabetic kidney disease is the leading cause of end-stage renal failure worldwide, however current treatments remain suboptimal. diabetic kidney disease is the leading cause of end-stage renal failure worldwide, however current treatments remain suboptimal. persistent hyperglycemia can damage the kidneys and leads to retinopathy through various mechanisms. recently various plants have shown beneficial effects not only on kidney function in diabetes mellitus (1,2), but also on kidney toxicities induced by some drugs or toxins (1–3). it has been shown that metformin, a biguanide blood sugar regulatory compound from a herbal source (galega officinalis), may be useful in the prevention of kidney injury (3–7).
some herbal drugs have a positive influence on glucose homeostasis in diabetic patients. some other plants lower blood pressure or improve the kidney and cardiovascular functions which are often disturbed in diabetic patients (6–8). renal injury is usually associated with an increase in oxidative stress and the oxidative stress induced renal damage is reduced by antioxidants. people with low intake of vegetables and fruits have been shown to be at more risk for development of renal injury. the findings about combination antioxidants are also complicated and not entirely clear (5–11). please cite this paper as: mardani s, nasri h, rafieian-kopaei m, hajian s. herbal medicine and diabetic kidney disease.
a lot of western medicines such as acei and arb have been demonstrated to protect renal function of dn but are not enough to delay or retard the progression of dn; therefore, exploring exact and feasible drug is current research hotspot in medicine. crcc has been shown to protect renal function and slow down the progression of dn by the suppression of tgf-β1 and type iv collagen expression in stz induced diabetic rats [21]. in a multicenter randomized clinical study, qjc has been shown to reduce urinary protein effectively and delay the progression of renal function in treating 3b dn patients [36]. tsl has been shown to decrease the levels of fbg, hba1c, and urinary malb in the subtotal nephrectomy plus stz induced diabetic rats and decrease the components of ecm through downregulating tgf-β1 and timp-2 and upregulating mmp-2 expression [45]. one study has shown that zhm could prevent the process of dn by decreasing the expression of tgf-β1 and type iv collagen in hg stimulated human glomerular mesangial cells [55].
in the treatment of dn in db/db mice, curcumin has been shown to decrease albuminuria and attenuate glomerular sclerosis by inhibiting phosphorylation of stat3 and degradation of iκb [67]. icariin is a major constituent of flavonoid extracted from the plant herba epimedii and has been shown to relieve renal damage in stz induced diabetic rats through inhibiting the expression of tgf-β1 and collagen iv protein [79]. panax notoginoside (pns) is extracted from radix notoginseng and has been shown to protect kidney in type 1 diabetic rats at early stage through inhibiting the expression of vegf protein and enhancing bmp-7 expression in the kidney [89]. a previous study showed that sm could protect stz induced diabetic rats from dn by suppressing the overexpression of tgf-β1, ctgf, pai-1, and fn in renal cortex [101]. (vombp), extracted from herbal tcm magnolia biondii pamp., has been reported to protect the kidney in stz induced diabetic rats by inhibiting the expression of p-selectin in serum and renal tissue [109]. in order to avoid the toxicity and side effects of tcm formulas, there is increasing interest in studying single herbal tcm especially monomers from single herbal tcm on dn.
some other herbal medicines such as curcumin from curcuma longa, panax quinquefolium, vitis vinifera and glycosides from stelechocarpus berberine (bbr), an effective compound of herbal tcm, includes coptis chinensis, hydrastis canadensis, berberis aristata, berberis aquifolium, and arcangelisia north american ginseng has preventive effects on dn and it works through its antihyperglycemic and antioxidant activities [151sen s, chen s,, related conditions, related conditions, related symptoms, natural treatment for microalbuminuria, foods to avoid with kidney disease and diabetes.
also, from the 5,901 chm prescriptions, we found ji-sheng-shen-qi-wan, astragalus mongholicus bunge or (astragalus membranaceus (fisch.) bge.), abstract ; ganoderma lucidum (family: ganodermataceae; ; the effects of lucidum ; ginkgo biloba (family: ginkgoaceae; common name: ; glycine max fabaceae; common the following herbal substances might be considered as promising agents for application in diabetic nephropathy: galega officinalis, glycyrrhiza, .
When you try to get related information on herbal treatment for diabetic nephropathy, you may look for related areas. related conditions, related symptoms, natural treatment for microalbuminuria, foods to avoid with kidney disease and diabetes.