the hallmark symptoms of ss are dry eyes and mouth, compromising the quality of life of patients and decreasing their capacity to perform their daily activities. ), and “sheng-di-huang” (rehmannia glutinosa libosch) as the core components of tcm therapeutic prescriptions for ss in taiwan. lastly, we found that ss-1 also inhibited the expression of ifn-γ and th2 cytokines, and moderately down-regulated il-17a expression in ss patients’ peripheral blood mononuclear cells (pbmcs). ss-1 comprised a 2:1:1 ratio of “gan-lu-yin,” “sang-ju-yin,” and “xue-fu-zhu-yu decoction” in powder form; details of the composition of ss-1 and its certification, previously reported by chang et al. the trial outcomes were analyzed using the per-protocol model, and outcome differences between the ss-1–placebo and placebo–ss-1 groups were evaluated through analysis of variance in a 2 × 2 crossover design. thus, a total of 70 patients remained for randomization, of whom 36 were placed in the placebo–ss-1 group, and the other 34 in the ss-1–placebo group. of the subjects who completed the trial, 65 had primary ss and the other five, secondary ss. translational research approaches using in vitro biomap systems were followed by taiwan’s first clinical trial to evaluate the therapeutic efficacy and potential underlying mechanism(s) of ss-1 for the treatment of ss. our results suggest that ss-1 may regulate the levels of both baff and bcma, resulting in the down-regulation of lymphocyte activity. however, the efficacy of schirmer’s tests of the per-protocol analysis could be examined between the treatment period and placebo period in the same individual ss subject. cc, yw, ky, and hc were also responsible for drafting and revision of the article. role of matrix metalloproteinases 2 and 9 in lacrimal gland disease in animal models of sjögren’s syndrome. characterization of compound mechanisms and secondary activities by biomap analysis. high circulating level of interleukin-18 in patients with primary sjögren’s syndrome is associated with disease activity. efficacy and safety of pilocarpine for radiation-induced xerostomia in patients with head and neck cancer: a systematic review and meta-analysis.
clinical parameter and th17 related to lymphocytes infiltrating degree of labial salivary gland in primary sjögren’s syndrome. the effectiveness and safety of total glucosides of paeony in primary sjögren’s syndrome: a systematic review and meta-analysis. effects of hydroxychloroquine on symptomatic improvement in primary sjögren syndrome: the joquer randomized clinical trial. t cell-associated cytokines in the pathogenesis of sjögren’s syndrome. phenotypic screening of the toxcast chemical library to classify toxic and therapeutic mechanisms. meta-analysis of the efficacy in treatment of primary sjögren’s syndrome: traditional chinese medicine vs western medicine. il-27-induced modulation of autoimmunity and its therapeutic potential. salivary gland tissue expression of interleukin-23 and interleukin-17 in sjögren’s syndrome: findings in humans and mice. comparison of the discontinuation rates and side-effect profiles of pilocarpine and cevimeline for xerostomia in primary sjögren’s syndrome. topical and systemic medications for the treatment of primary sjögren’s syndrome. reliability and validity of the ocular surface disease index. eular sjogren’s syndrome disease activity index: development of a consensus systemic disease activity index for primary sjogren’s syndrome. the clinical application and research progress of xie-fu-zhu-yu-tang. incidence and mortality of treated primary sjogren’s syndrome in taiwan: a population-based study. pilocarpine hydrochloride for the treatment of xerostomia in patients with sjögren’s syndrome in taiwan-aa double-blind, placebo-controlled trial. disturbance of cytokine networks in sjögren’s syndrome.
catalpol, the active ingredient in a medicinal herb often used for sjögren’s syndrome treatment, eases disease symptoms by altering the balance and communication of specific immune cells, a study in mice suggests. in the study, researchers at the nanjing university of chinese medicine set out to investigate if catalpol can reduce the signs and symptoms associated with the condition, and the mechanisms used to achieve such benefits. experiments were performed on non-obese and diabetic (nod) mice, a strain that spontaneously develops symptoms of sjögren’s syndrome — salivary infections, immune cell infiltration, reduced saliva flow, and autoantibodies — which mimic the condition in humans. looking at water intake and salivary flow rates, which are overall measures for symptom severity, the researchers found that catalpol significantly protected mice from disease symptoms. by the end of treatment, the animals receiving catalpol had normal water intake and saliva production, while control animals were drinking significantly more water and their saliva flow had decreased significantly.
attempting to determine how catalpol prevented disease symptoms, the researchers examined the mice more closely to monitor for any changes in immune system activity. these immune changes decreased the abnormal formation of structures, called germinal centers, that act as hubs for immune system activity in salivary glands and other atypical locations. “our work indicates that catalpol might be a potential substance to ameliorate primary sjogren’s syndrome in a nod mice model by modulating tfr and tfh cells,” the researchers said. nevertheless, they noted that additional research is needed to determine how catalpol influences t-cells and inflammatory molecules, and suggest that transgenic mice (that have human dna) would be a logical next step. this content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
hence, the tcm treatment approach is to “enrich yin, clear heat and moisten dryness,” commonly using chinese formulas and single herbs that catalpol, the active ingredient in a medicinal herb often used for sjögren’s syndrome treatment, eases disease symptoms by altering the for best results, drink a couple of cups of tea with cinnamon oil, lemon and honey each day while symptoms persist. pour very warm (not boiling), chinese herbs for sj gren s syndrome, chinese herbs for sj gren s syndrome, how i cured my sjogren’s syndrome, sjögren’s syndrome and vitamin deficiencies, long-term effects of sjögren’s syndrome.
background. there is no curative treatment for primary sjögren’s syndrome (pss). chinese herbal medicine (chm) is widely used in the treatment of pss in china. table 2: – using herbal mouthwash (caries prevention) e.g., mentha spicata (spearmint) -gargling with mucilage herbs as a saliva substitute, such as blond was the most commonly used formula and single herb, respectively. “qi-ju-di-huang-wan, gan-lu-yin, xuan-shen, mai-men-dong (ophiopogon japonicus, turmeric for sjogren’s syndrome, what is the best treatment for sjögren’s syndrome. herbs and supplements for sjogren’s syndromecysteine.evening primrose.gamma-linolenic acid (gla)omega-6 fatty acids.sulfur.
When you try to get related information on herbs for sjogren’s syndrome, you may look for related areas. chinese herbs for sjögren’s syndrome, how i cured my sjogren’s syndrome, sjögren’s syndrome and vitamin deficiencies, long-term effects of sjögren’s syndrome, turmeric for sjogren’s syndrome, what is the best treatment for sjögren’s syndrome.