researchers at the kimmel cancer at jefferson in philadelphia have found that thymoquinone, an extract of nigella sativa seed oil, blocked pancreatic cancer cell growth and killed the cells by enhancing the process of programmed cell death. while the studies are in the early stages, the findings suggest that thymoquinone could eventually have some use as a preventative strategy in patients who have gone through surgery and chemotherapy or in individuals who are at a high risk of developing cancer. using a human pancreatic cancer cell line, she and her team found that adding thymoquinone killed approximately 80 percent of the cancer cells. they demonstrated that thymoquinone triggered programmed cell death in the cells, and that a number of important genes, including p53, bax, bcl-2 and p21, were affected. the p21 gene, which is involved in the regulation of different phases of the cell cycle, was substantially increased. dr. arafat and her co-workers also found that thymoquinone caused “epigenetic” changes in pancreatic cancer cells, modifying the cells’ dna.
in this case, it could involve the genes that are key to initiating programmed cell death. “we looked at the status of the histones and found surprisingly that thymoquinone increased the acetylation process,” dr. arafat says. dr. arafat notes that hdac inhibitors are a “hot” new class of drugs that interfere with the function of histone deacetylases, and is being studied as a treatment for cancer and neurodegenerative diseases. pancreatic cancer, the fourth-leading cause of cancer death in this country, takes some 34,000 lives a year. the disease frequently is detected after it has spread and only 4 percent of individuals with pancreatic cancer live for five years after diagnosis. or view hourly updated newsfeeds in your rss reader: tell us what you think of sciencedaily — we welcome both positive and negative comments.
we are not averse to alternative, complementary, or holistic treatment modalities for pancreatic cancer in which the downside risks are minimal (or better yet, nonexistent) and which do not appear likely to interfere with other more conventional medical therapies. to those people, we would encourage thoughtful and cautious approaches to the more gentle of the alternative, complementary, and/or holistic treatments of pancreatic cancer. in our attempt to suggest tempering faith and hope with rationality and care, we would advise being careful. we have discussed such treatment and others in our pancreatica blog, and include titles and dates of articles found in the medical literature (both below).
donations go directly to promoting awareness, increasing education, furthering pancreatic cancer research aimed at early diagnosis and, helping patients and families impacted by the effects of pancreatic cancer. your monthly gift will go directly to promoting awareness, increasing education, furthering pancreatic cancer research aimed at early diagnosis and, helping patients and families impacted by the effects of pancreatic cancer. pancreatic cancer is expected to become the 2nd leading cause of cancer-related death by the year 2020. there are many reasons why the outcome for pancreatic cancer patients is much bleaker than for most other cancer types. together with you our mission is to promote awareness, increase education, and further pancreatic cancer research aimed at early diagnosis. patients can expect as low as a 9% chance to live for at least five years treatment with lutathera – study shows promise – a new study published in the journal of nuclear medicine shows long-term effectiveness by prrt in treating malignant in late march 2017, the french biotech firm erytech presented results of a iib clinical trial of eryaspase (trade name: graspa) which is the enzyme
an herb used in traditional medicine by middle eastern countries may help fight pancreatic cancer. researchers have found that thymoquinone, the preliminary results suggest that a combination of curcumin and gemcitabine for the patients with advanced pancreatic cancer is feasible. mistletoe extracts the 8 major ingredients are dendranthema morifolium tzvel, ganoderma lucidum karst, glycyrrhiza glabra l., isatis indigotica fort, panax pseudoginseng wall,, .
researchers at the kimmel cancer at jefferson in philadelphia, us, have found that thymoquinone, an extract of nigella sativa (black seed) seed some of the most common alternative, complementary and holistic drug agents and treatment modalities that have been studied for pancreatic cancer include biological intra‑control cancer treatment (bict) is a novel systemic therapy involving palliative care and herbal extract combinations [, .
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