astragalus, known as huáng qí in chinese, is a flowering plant that is native to parts of china, mongolia, and korea. in the world of oncology, astragalus is unique in that it is perhaps one of our most well-studied herbs, specifically for lung cancer. according to cancer.gov, the chance of being alive 5 years after a diagnosis of lung cancer is less than 20%. the most common type of lung cancer is called non-small cell lung cancer (nsclc), which represents 80% of all lung cancers. in addition to surgery (if possible) and radiation, treatment for nsclc often includes a platinum chemotherapy drug, a type of chemo which acts by forming cross-links in the dna strands of cancer cells, essentially shoving a monkey wrench into the process of cancer cell division.
several randomized clinical trials have been conducted to investigate whether the addition of astragalus to platinum-based chemotherapy could improve outcomes in nsclc compared to chemotherapy alone. in this meta-analysis, adding astragalus to a platinum-based chemotherapy regimen significantly improved overall survival, by 26% at year 1, 67% at year 2, and 70% at year 3. in addition, patients who took astragalus alongside chemotherapy had significantly higher tumor response rates, meaning that their tumors were more likely to decrease in size and number. perhaps the most interesting finding, however, was that when patients received an astragalus-based formula based on traditional chinese medicine pattern differentiation, the beneficial effects were greater than when patients received either a standalone astragalus supplement or an astragalus injection. regardless, taking astragalus alongside platinum-based chemotherapy for patients with nsclc appears to be a safe and significantly beneficial addition based on the current evidence. 2016;23(3):e188-195 sage cancer care | 1836 ne 7th ave, ste #205 | portland, or 97212phone 503-206-6218 | fax 888-972-1720
apoptotic cell death was induced in a549 cells by these effective extracts via the mitochondria-mediated pathway. in both sexes combined, lung cancer is the most diagnosed cancer (11.6% of the total cases) and the leading cause of cancer death (18.4% of the total cancer deaths) worldwide [2]. in addition, the combination of c. oblongifolius and c. sublyratus had been used as a treatment for gastric ulcers and gastric cancer in thai traditional medicine [14]. at 24 h incubation, the percentages of cell viability of a459 cells were significantly decreased at a dose dependent manner by treatment with bea, cea, eea, and ee extracts, but not with be and ce. the number of cells with condensed nuclei and apoptotic bodies increased in a dose dependent manner for all of the effective extracts (figure 5). the results showed that all of the primary lung cancer samples were sensitive to cea and ee, but only three cancer samples were resistant to bea and only two cancer samples were resistant to eea. the a549 cell line is made up of adenocarcinoma from human alveolar basal epithelial cells which are commonly used as a model for the study of lung cancer and for the development of drug therapies [35]. the most effective extract against a549 cells and the only extract that had a significant effect on primary lung cancer cells was ee. currently, chemotherapy is the main treatment for lung cancer and is a palliative remedy for patients. a reduction of ∆ψm was determined and it was found that the percentage of cells with a loss of ∆ψm increased after treatment of a549 with the effective extracts.
the effective extracts induced ros generation and noxa upregulation in a549 cells leading to a loss of ∆ψm and apoptotic cell death via the mitochondrial pathway. the number of sensitive samples showed that cea and ee were effective against cancer samples from every patient, but no sample was sensitive to bea and eea. however, the effect of ee in apoptosis induction and ∆ψm reduction was less effective than the other three effective extracts, whereas ee induced ros generated around 1.5-fold of control which was the same as the other three extracts. the percentages of reduction in cell viability were compared to untreated control cells and then the inhibitory concentration (ic) values were calculated. the cells were treated with the effective extracts at ic10, ic20, and ic50 for 24 h and then stained with dioc6 at a final concentration of 40 nm for 15 min. after treatment with the effective extracts at ic10, ic20, and ic50 and 0.3% of h2o2 (positive control) for 4 h, the cells were stained with dcfh-da at a final concentration of 2 µm for 30 min. four of these extracts (bea, cea, eea, and ee) induced human lung cancer cell apoptosis in the a549 cell line. this was the most effective extract against both the a549 cancer cell line and the primary lung cancer cells. the cells were treated with mtx or ets alone, and combination of mtx + bea, mtx + ee, and ets + ee. the percent of the cells with ∆ψm loss after cells which were treated by (a) bea, (b) cea, (c) eea, and (d) ee are shown on the bar graphs (lower). ** p-values of the sensitive cell were calculated by fisher exact test for comparing the proportions of the number of cancer and normal in sensitive group.
yangzheng xiaoji: another herbal blend that is used to treat lung cancer is yangzheng xiaoji, a formula of 14 herbs traditionally used to treat cancer in explore lung cancer alternative treatments and therapies, and natural treatments like acupuncture, massage, yoga, meditation, and aromatherapy. astragalus has a long history of use in chinese medicine for a variety of ailments and has increasingly been used in the west for its, .
some say that “natural” therapies like herbal medicine, cannabis oil, laetrile (a purified form of a compound found in fruit pits or seeds), or the three herbal species studied were bridelia ovata decne, croton oblongifolius roxb., and erythrophleum succirubrum gagnep. b. ovata and c. 2. results and discussion ; cassia garrettiana thailand, dried heartwood ; sophora flavescens, china, dried root ; sutherlandia frutescens, south africa, fresh, . are herbs and spice beneficial for lung cancer patients?ginger. whether used as a fresh root or ground powder, ginger can provide benefit for the lung cancer patient. turmeric. turmeric is a member of the curcumin family. cinnamon. cinnamon is one of the most popular spices in the american culture. herbs. garlic.
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