pancreatic cancer is a type of common malignant tumors with high occurrence in the world. unfortunately, most patients with locally advanced and metastatic pancreatic cancers could not benefit from the monotherapy of gemcitabine. however, compared with tumors in other sites, the overall survival of the patients with pancreatic cancer is unsatisfactory and the toxicity of radiotherapy is obvious. moreover, psorospermin combined with gemcitabine was found to have an at least additive effect in slowing the growth of miapaca pancreatic cancer cells . in association with the suppression of nf-κb, holcomb et al. indicated that piperlongumine enhanced the antitumor properties of gemcitabine in human pancreatic cancer cells in vitro and in vivo by modulating the nf-kappab pathway .
showed zyflamend in combination with gemcitabine synergically inhibited the growth of human pancreatic cells in vitro and in vivo by inhibiting nf-κb signaling pathways . showed the combination of the extract of pao pereira and gemcitabine had a synergistic effect in inhibiting growth and inducing apoptosis of pancreatic cancer cells . indicated that the combination of sulforaphane with hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin synergistically inhibited cell growth in vitro and in pancreatic cancer xenograft model in vivo, by decreasing the function of hsp90 and increasing the activity of caspase-3 . the combination of lovastatin and berberine slightly, but significantly, decreased tumor growth in a panc 02 pancreatic cancer model of mice. the preliminary results suggest that a combination of curcumin and gemcitabine for the patients with advanced pancreatic cancer is feasible. the results demonstrated that treatment of pancreatic cancer patients with axp107-11 in combination with gemcitabine led to a favorable pharmacokinetics with high serum levels without toxicity. chinese herbal medicine can increase the effect of antitumor therapies and improve the quality of life or the performance status of pancreatic cancer patients, which will provide more evidence to promote the application of chinese herbal medicine to benefit the patients with pancreatic cancer in the world.
therefore, there is a need to investigate and clarify the potential benefits and safety issues of chm for pancreatic cancer patients. patients received chm in the form of concentrated chm granules that were prescribed by the same cmp for at least 3 months, and all costs were borne by the patients themselves. calculation of os is presented in table 1. the survival and treatment conditions are summarized in table 2. os ranged from 4 months to 9.6 years, with a mean survival of 29.6 months and a median survival of 15.2 months. follow-up prescriptions were adjusted based on the assessment of inadequate anticancer regimen and supplement deficiency with adherence to the syndrome differentiation practice of tcm. in october 2009, the patient stopped chm treatment for a little over 1 year. in may 2011, case 4 (female, age 58 years) sought medical consultation due to anemia and lack of appetite, and she was diagnosed with pancreatic head cancer. the tumor shrank and was surgically removed.
further examination confirmed the diagnosis of pancreatic head cancer with liver and bone metastasis. after 1 year, 4 months of both chinese and conventional medicine, he died in october 2014. the total survival time was close to 2 years. the generalizability of the study was considered; patients from different sex and age groups were recruited, and the age distribution was similar to that of pancreatic cancer patients in hong kong. this study can facilitate discussion on the role of chm in treating pancreatic cancer. 0001021 (case 3), with a low-density carcinoma block in the pancreatic body, and liver metastasis. they caused obstruction to the pancreatic duct with atrophic change in distal body and tail of pancreas. the rest of pancreas was unremarkable.
spes contains 15 herbs: cervus nippon, pyrola rotundifolia, panax ginseng, ganoderma japonicum, agrimonia pilosa, cistanche deserticola, corydalis bulbosa, the 8 major ingredients are dendranthema morifolium tzvel, ganoderma lucidum karst, glycyrrhiza glabra l., isatis indigotica fort, panax pseudoginseng wall, recent studies have demonstrated that cannabis sativa (marijuana), nigella sativa (black seed), annona muricata (soursop), curcuma longa (, .
an herb used in traditional medicine by middle eastern countries may help fight pancreatic cancer. researchers have found that thymoquinone, an extract of nigella sativa seed oil, blocked pancreatic cancer cell growth and killed cells by enhancing programmed cell death. some of the most common alternative, complementary and holistic drug agents and treatment modalities that have been studied for pancreatic cancer include biological intra‑control cancer treatment (bict) is a novel systemic therapy involving palliative care and herbal extract combinations [ tumeric, for example, is one such herb which has an increasing amount of literature to support the use of the herbal medicine in cancer. ribraxx, .
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