the study, published in cancer cell, looked at cell cultures and in vivo mouse experiments to see how the release of a t-cell cytokine called interferon gamma combined with arachidonic acid, a fatty acid, leads to a type of cell death called ferroptosis via targeting the enzyme acsl4. ferroptosis has been found to occur in tumor cells and play a role in cancer immunity. “targeting acsl4 may help in understanding and expanding possible immunotherapy options,” said weiping zou, m.d., ph.d., director the center of excellence for cancer immunology and immunotherapy and lead researcher on this study. “but in this study, we defined a new way that it works.” this study shows that combining interferon gamma with arachidonic acid, a fatty acid found in the tumor microenvironment, activates acsl4, alters tumor cell lipid pattern, and naturally induces tumor cell ferroptosis.
“targeting acsl4 sensitizes cancer to immunotherapy.” zou’s lab was the first to identify a role for ferroptosis in cancer immunity and therapy, highlighting the possibility of targeting this pathway to improve the effectiveness of immunotherapy in people with cancer. while immunotherapy has dramatically changed outcomes in melanoma, lung cancer and other cancer types, the treatments work for only about 30% of people with cancer. “this study raises a lot of questions for us to keep exploring, particularly around the basic biology of cell ferroptosis, including the involvement of different fatty acids and dietary lipids, the different roles immune cells play in ferroptosis, and how to target acsl4 and ferroptosis pathways,” zou said. you are free to copy, distribute, adapt, transmit, or make commercial use of this work as long as you attribute michigan medicine as the original creator and include a link to this article.
the precision medicine research conducted at the mu school of medicine is part of nextgen precision health, an initiative to expand collaboration in personalized health care and the translation of interdisciplinary research for the benefit of society. new and innovative treatments emerge each year in the fight against cancer, and mu health care physicians and researchers have set their sights on one promising method, immunotherapy, to develop new strategies and improve outcomes for patients everywhere. occasionally, an altered cell is able to disguise itself from the immune system. “this happens through a sequence of events where the cancer cells meet up with immune cells, target the immune cells’ receptors that recognize cancerous cells and systematically turn them off,” kimchi says. “the key is, can we reverse that process?” kimchi asks.
“the more specific we can make the treatments, then the better and more safely we can treat our patients,” kimchi says. kimchi and others at mu health care are building on decades of immunotherapy research to make highly targeted immune therapy drugs. that’s through hepatitis c infections and through the development of fatty liver disease, which may be related to our diet and the rise in obesity.” mu doctors study the unique traits of liver cancer cells in hopes of identifying drugs that will help the body’s immune system recognize rogue liver cells as a threat. this is how immunotherapy is a game changer in that it crosses the boundaries of different cancers, and it’s broadly applicable.” as for patients at ellis fischel, kimchi says, “we have a unique, multidisciplinary approach. but regardless of the disease and what the ultimate treatment is, we develop a specific plan, as a group, for each person in our care.”
this study shows that combining interferon gamma with arachidonic acid, a fatty acid found in the tumor microenvironment, activates acsl4, while it’s unlikely that a “silver bullet” treatment will be discovered that can destroy all types of cancer, kimchi believes the field immunotherapy will cancer immunotherapy is a highly successful and rapidly evolving treatment modality that works by augmenting the body’s own immune system., natural immunotherapy supplements, natural immunotherapy supplements, nk cells for cancer immunotherapy, natural killer cells, how do nk cells kill cancer cells.
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