some of these chms have been investigated and verified to be beneficial in alleviating chemotherapy-related side effects (qi et al., 2010). specifically, oxaliplatin is frequently used in combination with folinic acid (lv) and 5-fu to formulate the folfox regimen, which serves as an adjuvant therapy for crc. furthermore, studies also confirmed that niuche shenqi wan didn’t interfere the anti-tumor effect of oxaliplatin both in vitro and in vivo (ushio et al., 2012). ac591 is a standardized extract from huangqi guizhi wuwu decoction, which has been reported to lower the incidence and relieve the severity of neurotoxicity in patients undergoing the folfox regimen. “chen” (minister) is usually utilized to enhance the function of “jun.” “zuo” (adjuvant) plays a role in reducing the toxicity of other herbs and treating accompanying symptoms. lonicerae flos, one herb in these prescriptions, was found to suppress the expression of cox-2, il-1, and il-6 (schröder et al., 2013). moreover, banxia xiexin decoction was also found to outstandingly delay the onset of diarrhea in patients treated with cisplatin and irinotecan in a randomized controlled trial (rct) (mori et al., 2003). intestinal mucositis is one of the most frequently encountered side effects in crc patients undergoing chemotherapy regimens, such as 5-fu and irinotecan. in addition, liujunzi decoction was also shown to alleviate cniv in patients undergoing cisplatin and paclitaxel regimen (ohnishi et al., 2017). moreover, it is critically important to further identify whether chms have effects on the metabolism of chemotherapeutic reagents and anti-tumor efficacy in clinical trial. metabolism of irinotecan to sn-38 in a tissue-isolated tumor model. toxicity associated with capecitabine plus oxaliplatin in colorectal cancer before and after an institutional policy of capecitabine dose reduction. integrative medicine for relief of nausea and vomiting in the treatment of colorectal cancer using oxaliplatin-based chemotherapy: a systematic review and meta-analysis. leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. wen-luo-tong prevents glial activation and nociceptive sensitization in a rat model of oxaliplatin-induced neuropathic pain. in vitro evidence for the use of astragali radix extracts as adjuvant against oxaliplatin-induced neurotoxicity. phase i/iia randomized study of phy906, a novel herbal agent, as a modulator of chemotherapy in patients with advanced colorectal cancer.
shengjiang xiexin decoction alters pharmacokinetics of irinotecan by regulating metabolic enzymes and transporters: a multi-target therapy for alleviating the gastrointestinal toxicity. current pharmacotherapy for chemotherapy-induced nausea and vomiting in cancer patients. preventive effects of hange-shashin-to on irinotecan hydrochloridecaused diarrhea and its relevance to the colonic prostaglandin e2 and water absorption in the rat. phase 1/2 clinical study of irinotecan and oral s-1 (iris) in patients with advanced gastric cancer. efficacy of goshajinkigan for peripheral neurotoxicity of oxaliplatin in patients with advanced or recurrent colorectal cancer. a phase i study of the chinese herbal medicine phy906 as a modulator of irinotecan-based chemotherapy in patients with advanced colorectal cancer. clinical study on the prevention of oxaliplatin-induced neurotoxicity with guilongtongluofang: results of a randomized, double-blind, placebo-controlled trial. 5-fluorouracil: mechanisms of action and clinical strategies. a survey of chinese medicinal herbal treatment for chemotherapy-induced oral mucositis. the clinical impact of hangeshashinto (tj-14) in the treatment of chemotherapy-induced oral mucositis in gastric cancer and colorectal cancer: analyses of pooled data from two phase ii randomized clinical trials (hangesha-g and hangesha-c). additive effect of rikkunshito, an herbal medicine, on chemotherapy-induced nausea, vomiting, and anorexia in uterine cervical or corpus cancer patients treated with cisplatin and paclitaxel: results of a randomized phase ii study (jortc kmp-02). twelve weeks of protracted venous infusion of fluorouracil (5-fu) is as effective as 6 months of bolus 5-fu and folinic acid as adjuvant treatment in colorectal cancer. doi: 10.1016/j.intimp.2008.06.008 shukla, y., and singh, m. (2007). lactobacillus fermentum br11 and fructo-oligosaccharide partially reduce jejunal inflammation in a model of intestinal mucositis in rats. protective effects of kampo medicines and baicalin against intestinal toxicity of a new anticancer camptothecin derivative, irinotecan hydrochloride (cpt-11), in rats. the traditional japanese medicine rikkunshito promotes gastric emptying via the antagonistic action of the 5-ht receptor pathway in rats. carbamazepine for prevention of oxaliplatin-related neurotoxicity in patients with advanced colorectal cancer: final results of a randomised, controlled, multicenter phase ii study. metabolism of irinotecan and its active metabolite sn-38 by intestinal microflora in rats.
overall, results indicate that grape, soybean, green tea, garlic, olive, and pomegranate are the most effective plants against colon cancer. in fish oil reduces proliferation in upper-crypt cells of patients with a history of colonic polyps, inhibits colon tumors, in combination with some supplements and herbs may help reduce side effects from conventional medications. others may help reduce the risk of developing colorectal, .
natural remedies for colon cancer prevention vitamin d folate quercetin tea. as a natural product-derived drug, irinotecan remains the backbone of combination chemotherapies for metastatic crc, including folfiri (levoleucovorin (lv) and specifically, ginger, astragali radix, and liujunzi decoction have been verified to ameliorate nausea and vomiting. banxia xiexin decoction and, .
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