researchers at the kimmel cancer at jefferson in philadelphia have found that thymoquinone, an extract of nigella sativa seed oil, blocked pancreatic cancer cell growth and killed the cells by enhancing the process of programmed cell death. while the studies are in the early stages, the findings suggest that thymoquinone could eventually have some use as a preventative strategy in patients who have gone through surgery and chemotherapy or in individuals who are at a high risk of developing cancer. using a human pancreatic cancer cell line, she and her team found that adding thymoquinone killed approximately 80 percent of the cancer cells. they demonstrated that thymoquinone triggered programmed cell death in the cells, and that a number of important genes, including p53, bax, bcl-2 and p21, were affected. the p21 gene, which is involved in the regulation of different phases of the cell cycle, was substantially increased. dr. arafat and her co-workers also found that thymoquinone caused “epigenetic” changes in pancreatic cancer cells, modifying the cells’ dna.
in this case, it could involve the genes that are key to initiating programmed cell death. “we looked at the status of the histones and found surprisingly that thymoquinone increased the acetylation process,” dr. arafat says. dr. arafat notes that hdac inhibitors are a “hot” new class of drugs that interfere with the function of histone deacetylases, and is being studied as a treatment for cancer and neurodegenerative diseases. pancreatic cancer, the fourth-leading cause of cancer death in this country, takes some 34,000 lives a year. the disease frequently is detected after it has spread and only 4 percent of individuals with pancreatic cancer live for five years after diagnosis. or view hourly updated newsfeeds in your rss reader: tell us what you think of sciencedaily — we welcome both positive and negative comments.
pancreatic cancer is a type of common malignant tumors with high occurrence in the world. unfortunately, most patients with locally advanced and metastatic pancreatic cancers could not benefit from the monotherapy of gemcitabine. however, compared with tumors in other sites, the overall survival of the patients with pancreatic cancer is unsatisfactory and the toxicity of radiotherapy is obvious. moreover, psorospermin combined with gemcitabine was found to have an at least additive effect in slowing the growth of miapaca pancreatic cancer cells . in association with the suppression of nf-κb, holcomb et al. indicated that piperlongumine enhanced the antitumor properties of gemcitabine in human pancreatic cancer cells in vitro and in vivo by modulating the nf-kappab pathway .
showed zyflamend in combination with gemcitabine synergically inhibited the growth of human pancreatic cells in vitro and in vivo by inhibiting nf-κb signaling pathways . showed the combination of the extract of pao pereira and gemcitabine had a synergistic effect in inhibiting growth and inducing apoptosis of pancreatic cancer cells . indicated that the combination of sulforaphane with hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin synergistically inhibited cell growth in vitro and in pancreatic cancer xenograft model in vivo, by decreasing the function of hsp90 and increasing the activity of caspase-3 . the combination of lovastatin and berberine slightly, but significantly, decreased tumor growth in a panc 02 pancreatic cancer model of mice. the preliminary results suggest that a combination of curcumin and gemcitabine for the patients with advanced pancreatic cancer is feasible. the results demonstrated that treatment of pancreatic cancer patients with axp107-11 in combination with gemcitabine led to a favorable pharmacokinetics with high serum levels without toxicity. chinese herbal medicine can increase the effect of antitumor therapies and improve the quality of life or the performance status of pancreatic cancer patients, which will provide more evidence to promote the application of chinese herbal medicine to benefit the patients with pancreatic cancer in the world.
an herb used in traditional medicine by middle eastern countries may help fight pancreatic cancer. researchers have found that thymoquinone, the preliminary results suggest that a combination of curcumin and gemcitabine for the patients with advanced pancreatic cancer is feasible. mistletoe extracts the 8 major ingredients are dendranthema morifolium tzvel, ganoderma lucidum karst, glycyrrhiza glabra l., isatis indigotica fort, panax pseudoginseng wall,, .
some of the most common alternative, complementary and holistic drug agents and treatment modalities that have been studied for pancreatic cancer include researchers at the kimmel cancer at jefferson in philadelphia, us, have found that thymoquinone, an extract of nigella sativa (black seed) seed alternative therapies include, but are not limited to the following disciplines: folk medicine, herbal medicine, diet fads, homeopathy, faith healing,, .
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