you are using a browser version with limited support for css. in the meantime, to ensure continued support, we are displaying the site without styles and javascript. in a randomized phase 2 trial, sotigalimab, a cd40 agonist, did not significantly improve overall survival in patients with previously untreated metastatic pancreatic cancer when combined with chemotherapy or with nivolumab and chemotherapy. blockade of erk signaling in kras-mutant pancreatic cancer increases the dependence on autophagic flux through different mechanisms and provides a rationale for combinatorial targeting with autophagy inhibitors. expression of hnf1a and krt81 stratifies pancreatic ductal adenocarcinoma tumors into different subtypes, and expression of cytochrome p450 3a5 mediates basal and/or drug-induced therapy resistance in each subtype.
the bromodomain and extraterminal (bet) inhibitor jq1 synergizes with the histone deacetylase inhibitor saha to suppress tumor growth in mouse models of pancreatic cancer. in a new study, miles wilkinson and colleagues now report that they have identified somatic mutations in an rna helicase encoded by upf1 in some pancreatic adenosquamous carcinomas. upf1 is required for nonsense-mediated rna decay, suggesting that the aberrant accumulation of altered rna transcripts may contribute to the malignant phenotype of these tumors and could be a target of diagnostic and therapeutic approaches for this tumor type. cepb4 is upregulated in human pancreatic adenocarcinomas and glioblastomas, where it supports tumor growth by providing translational activation of normally silent mrnas, including tpa, an important contributor to malignancy. the classical, quasimesenchymal and exocrine subtypes can further stratify tumors with the same genetic alterations, and could be useful to improve prognosis and predict treatment response.
you are using a browser version with limited support for css. in the meantime, to ensure continued support, we are displaying the site without styles and javascript. pancreatic cancer is a disease in which malignant cells originate in the pancreatic tissue. pancreatic cancer is generally characterized by a poor prognosis.
pancreatic intraepithelial neoplasia (panin) can develop into pancreatic ductal adenocarcinoma (pdac), however, the factors which determine how this occurs are unknown. lv, liu, mo and colleagues demonstrate that in pancreatic ductal adenocarcinoma cells, gasdermin e transports the transcription factor ybx1 to the nucleus, where it promotes the expression of mucins, thereby providing tumour cells with a barrier against digestive enzymes. patients with pancreatic ductal adenocarcinoma (pdac) usually have a dismal prognosis, and even after curative resection most patients will have disease relapse and ultimately die. the preopanc trial provides some evidence supporting the use of neoadjuvant therapy for patients with borderline resectable pdacs but not, as claimed, for those with resectable tumours. have identified a rare subpopulation of pancreatic acinar cells in the exocrine compartment that renews the pancreas by fuelling clonal expansion.
read the latest research articles in pancreatic cancer from nature medicine. erk and autophagy inhibition as a treatment approach for pancreatic cancer. pancreatic cancer is a disease in which malignant cells originate in the pancreatic tissue. cancer of the exocrine component of the pancreas (adenocarcinomas) “this study suggests there is benefit of combining immunotherapy and chemotherapy in patients with advanced pancreatic cancer and there may, pancreatic cancer new treatment 2021, pancreatic cancer new treatment 2021, pancreatic cancer new treatment 2022, pancreatic cancer review, pancreatic cancer research articles.
pancreatic ductal adenocarcinoma (pdac) is characterized by kras- and autophagy-dependent tumorigenic growth, but the role of kras in supporting autophagy immune evasion is a hallmark of kras-driven cancers, but the underlying causes remain unresolved. here, we use a mouse model of pancreatic ductal the findings, which appear in nature metabolism, also suggest a new potential strategy against pancreatic cancer by identifying critical, pancreatic cancer symptoms, what causes pancreatic cancer, effective drug combinations in breast, colon and pancreatic cancer cells, interesting facts about pancreatic cancer, good news about pancreatic cancer, pancreatic cancer news, combination of erk and autophagy inhibition as a treatment approach for pancreatic cancer, translational advances in pancreatic ductal adenocarcinoma therapy, the role of neoadjuvant therapy for resectable pancreatic cancer remains uncertain, pubmed.
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