the aim of the present work was to provide an overview of medicinal plants effective on colon cancer with special emphasis on bioactive components and underlying mechanisms of action. apart from these treatments, antiangiogenic agents are also used for the treatment and control of cancer progression [9]. since the current treatments usually have side effects, plants and their extracts can be useful in the treatment of colon cancer with fewer side effects. in case of any inconsistency, both authors reviewed the results together and solved the discrepancy.
the effects of the different medicinal plants and their extracts are essentially the same detected in in vitro studies. in an in vitro study, they inhibited cancer cell growth and induced apoptosis through the inhibition of the phosphoinositide 3-kinase/akt pathway. for instance, the extract prepared from the leaves of annona muricata inhibits the proliferation of colon cancer cells and induces apoptosis by arresting cells in the g1 phase [53]. in an in vitro study on the garcinia mangostana roots, the results were indicative of the inhibitory effect of the extract of this plant on p50 and p65 activation [93]. this is an open access article distributed under the creative commons attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
to put these data into the context of treatment responses seen in conventional medical practice, they also compared survival with pan-asian medicine + vitamins (pam+v) with that of concurrent external controls from kaiser permanente northern california and california cancer registries. our hypotheses were that (a) long-term use of pam+v would lead to longer survival than short-term use lasting only for the duration of chemotherapy/radiotherapy; and (b) pam+v combined with conventional therapy would improve survival, compared to conventional therapy alone. the herbal medicine portion of the pam+v protocol was administered in the traditional chinese method of giving patients dry herbs to take home and decoct. patients who were lost to follow-up and for whom treatment adherence was thus unknown were analyzed as part of the long-term adherence group, following the intention-to-treat principle.39 additionally, short-term versus long-term adherence was noted for both patients who after initial consultation here at pine street elected to continue at our center or follow up with other cam centers. in kaplan-meier plots, we found that in patients with all stages of colon cancer, treatment with both short-term and long-term pam+v resulted in longer survival than was seen in concurrent external controls from both kaiser permanente and ccr (figure 1).
survival at 2 years was 100% in both the long-term and short-term pam+v groups, 92% in kaiser controls, and 88% in ccr controls. we therefore compared the survival of the patients who used both long-term and short-term pam+v with that of cam users and nonusers from within the ccr database (figure 7). there may also have been other factors that could explain in part the survival differences of short-term over long-term pam+v; for example, patients choosing short-term pam+v therapy might have “felt healthier” and thus not maintained treatment. in practice, both methods of causal inference will balance the treatment groups, so that patients in each group are comparable with respect to confounding variables. colon cancer survival, showing all treatment combinations of pam+v and surgery, using california cancer registry patients as external controls abbreviation: pam+v, pan-asian medicine plus vitamins.
the results indicate that grape, soybean, green tea, garlic, olive, and pomegranate are the most effective plants against colon cancer. in these the chinese herbal medicines radix angelicae and radix paeoniae have been shown to protect intestinal cells from irradiation-induced damage. some supplements and herbs may help reduce side effects from conventional medications. others may help reduce the risk of developing colorectal, .
capecitabine, a highly active oral fluoropyrimidine, is an appealing alternative to 5-fu in the treatment of crc [93]. compared with 5-fu/lv, capecitabine has a specifically, ginger, astragali radix, and liujunzi decoction have been verified to ameliorate nausea and vomiting. banxia xiexin decoction and a practice combining physical postures, meditation and breathing techniques. yoga for those in cancer treatment tends to be low impact and gentle. yoga can, .
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