our data suggest that er ameliorates metabolic disorders and enhances the mrna expression of ppars in obese c57bl/6 mice induced by high-fat diet. recently, the water extract of rhizoma polygonati odorati has been shown to reduce blood glucose and to improve the glucose tolerance in diabetic mice and rats . the powder of er was dissolved in water to the final concentration of 1% for component analysis. at the end of the animal experiment study, mice were anesthetized and cardiac blood was taken. the chloroform layers were dried and dissolved in isopropyl alcohol to measure lipid levels as described . ferulic acid and 5-hydroxymethylfurfural were detected in the er by comparing the retention of the chromatographic images of standards (figure 1b and d). the combination of adiponectin and leptin has been reported to completely reverse insulin resistance in mice. the hf-fed mice showed higher levels of serum tc, tg and ldl-c when compared to that in chow control mice (figure 4e, p<0.05).
in therapeutic treatment, er treatment significantly increased the mrna expression of pparγ, α, pgc1-β, and ucp-2 and glut4, in the livers of mice (figure 6c, p<0.05). token together with finding of gtt and itt, the dada indicate that er could ameliorate leptin and insulin resistance in the mice. acc and aco are involved in triglyceride synthesis, the expression levels of which are known to increase in the steatotic livers of ob/ob mice . we found that er up-regulated the gene expression of ppars and its targets. er also up-regulated the mrna expression of pparγ, α and their target genes in the mice. the mice were fasted for 12 h and the tail vein blood was used to measure the blood glucose levels. tg (a) and tc (b) contents in the mouse liver of preventive treatment. the results represent three independent experiments, and data are presented as means ± sem.
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in traditional chinese medicine, the root of polygonatum odoratum, rhizoma polygonati odorati, is used both for food and medicine to prevent and treat metabolic disorders such as hyperlipidemia, hyperglycemia, obesity and cardiovascular disease. here, we examined the effect of the extract of rhizoma polygonati odorati (er) on metabolic disorders in diet-induced c57bl/6 obese mice. in the therapeutic study, we induced obesity in the mice and treated the obese mice with er for two weeks. we found that er treatments reduced serum tg and fasting blood glucose, and improved glucose tolerance in the mice.
druce belongs to the genus polygonatum family of plants. in traditional chinese medicine, the root of polygonatum odoratum, rhizoma polygonati druce belongs to the genus polygonatum family of plants. in traditional chinese medicine, the root of polygonatum odoratum, rhizoma polygonati rhizonia polygonati odorati (fragrant solomonseal rhizome) is the dried rhizome of polygonatum odoratum (mill) druce (family liliaceae), which grows wild and is, rhizoma polygonati benefits, rhizoma polygonati benefits, rhizoma dioscoreae, puerariae lobatae, fructus lycii.
it is indicated for dry cough with little phlegm, cough with blood, and hoarseness due to yin deficiency, dryness in lung with heat, because it can nourish lung rhizoma polygonati, or known as polygonatum and huang jing in mandarin, has long been considered as an amazing chinese herb that is good at its name in the chinese pharmacopoeia (2015 edition) is “polygonati rhizoma”. overview. polygonati odorati rhizoma and rhizoma polygonati are both listed in, polygonatum, cortex cinnamomi, flos caryophylli, radix ophiopogonis, huangjing.
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