seventy-nine men and women (40–90 years old) diagnosed as having mild to moderate osteoarthritis (oa) consumed either 500 mg/day of the up446 supplement or 440 mg/day of naproxen for 1 week in a double-blind randomized control trial. in the present study, we investigated the short-term effects of a proprietary dietary supplement known as up446 for the alleviation of pain associated with oa and for the improvement of knee joint mobility. after the initial prescreening over the telephone, eligible subjects were invited to the human performance laboratory of fsu’s department of nutrition, food, and exercise sciences for the final screening. subjects were seated in an upright position with the test leg secured at 90°, and the dynamometer arm rotor aligned to the lateral side of the knee joint. analysis of variance (anova) techniques were used to assess the effects of treatment and time. the effects of up446 supplementation on rom testing and 6mwt durations are shown in table 1. no group differences were found for either variable.
the use of complementary and alternative medicine in order to treat knee oa is quite common, with many individuals using multiple supplements.24 marketed dietary supplements and plant extracts are in high use for relieving symptomatic knee oa. thus, along with the present study, up446 has been shown to be efficacious in a rapid manner and may somewhat exceed the effect of certain nsaids. research personnel did their best to stress the difference between the feelings of pain and stiffness for greater accuracy. because tnf-α plays such a pivot role in the conservation of oa and is associated with greater radiographic of knee occurrences,35 1 week of treatment is unlikely a long enough duration to observe decreases, especially considering that many of the subjects were inactive prior to the 6mwt. in summary, the results of this study suggest that, similar to that of naproxen, up446 is capable of reducing perceived joint pain and stiffness while also improving joint flexibility. *p≤.05 for the analysis of variance (anova) comparison between baseline and final time points.
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scutellaria baicalensis is an herb used in traditional chinese medicine to treat a variety of conditions including hepatitis, infections, and cancer. a preliminary study of s. baicalensis along with metformin appeared to improved glucose tolerance, inflammation, and gut microbiota in patients with type 2 diabetes (23). in animal models, attenuation of asthma was attributed to reduced airway injury and restored mitochondrial function (19). elevated high-sensitivity c-reactive protein and high triglycerides were possibly related to ingestion of baicalein tablets in healthy subjects and should be monitored in future studies (25).
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