withania somnifera root

withania somnifera, known commonly as ashwagandha or winter cherry,[2][3][4] is an evergreen shrub in the solanaceae or nightshade family that grows in india, the middle east, and parts of africa. [3] although thought to be useful as a medicinal herb in ayurveda and sold in many countries as a dietary supplement, there is insufficient scientific evidence that it is safe or effective for treating any disease. tomentose branches extend radially from a central stem. the flowers are small, green and bell-shaped. [3] the latin species name somnifera means “sleep-inducing”. [3] withania somnifera is cultivated in many of the drier regions of india.




to propagate it can be grown from seed in the early spring, or from greenwood cuttings in the later spring. leaf spot disease caused by alternaria alternata is the most prevalent disease, which occurs in a severe form in punjab, haryana, and himachal pradesh. a decline in the concentration of its secondary metabolites occurs by leaf spot disease. [citation needed] the carmine red spider mite (tetranychus urticae) is the most prevalent pest of the plant in india. [11] the main phytochemical constituents are withanolides – which are triterpene lactones – withaferin a, alkaloids, steroidal lactones, tropine, and cuscohygrine. [3] withanolides are structurally similar to the ginsenosides of panax ginseng, leading to a common name for w. somnifera, “indian ginseng”. [4][12] the plant, particularly its root powder, has been used for centuries in traditional indian medicine, but there is no good evidence that it is safe or effective for treating any disease.

the crude extract of withania was tested for cytotoxicity against a375 cells by mtt assay. thus it might be said that the crude water extract of withania somnifera has potent cytotoxic effect on human malignant melanoma a375 cells. cells were treated with 350, 250 and 200 μg/ml of withania water crude extract for 24, 48 and 72 hr of incubation respectively. the cells were then treated with dapi to see the nucleus of control and treated cells.

in mtt assay we found a significant reduction of cell viability in case of treated cells (for 24, 48 and 72 hr) as compared to that of the control or vehicle treated cells. both the microscopic and dna fragmentation assays were indicating that withania somnifera crude water extract might initiate apoptosis in a375 cells. to the best of our knowledge, this is the first report of induction of apoptosis by withania somnifera crude water extract treatment in human malignant melanoma a375 cells. a375 cells were treated with different ic50 concentrations (350, 250 and 200 μg/ml) of water crude extract of withania somnifera for 24, 48 and 72 hr. one-way anova was applied to determine the difference between untreated control and withania treated group.

withania somnifera (ashawagandha) is very revered herb of the indian ayurvedic system of medicine as a rasayana (tonic). it is used for various kinds of withania somnifera (ashwagandha) attenuates antioxidant defense in aged spinal cord and inhibits copper induced lipid peroxidation and protein oxidative ashwagandha, also known by its botanical name withania somnifera, is a small woody plant with yellow flowers native to india and north africa. it’s classified, ashwagandha, ashwagandha, ashwagandha side effects, withania somnifera medicinal uses, ashwagandha plant.

ashwagandha, scientifically known as withania somnifera dunal, is an important medicinal plant in the ayurvedic system of medicine. the roots are highly valued, and are used either alone or in combination with other medicinal plants to treat a variety of ailments. withania somnifera, known commonly as ashwagandha or winter cherry, is an evergreen shrub in the solanaceae or nightshade family that grows in india, in ayurveda, withania somnifera is commonly known as ashwagandha, its roots are specifically used in medicinal and clinical applications. efficacy and safety of ashwagandha (withania somnifera) root extract in improving sexual function in women: a pilot study. biomed res int. 2015;, ashwagandha benefits for female, ashwagandha powder, ashwagandha for anxiety, ashwagandha tea benefits, ashwagandha reviews, ashwagandha ksm-66, ashwagandha dosage, ashwagandha powder how to use, is ashwagandha safe, ashwagandha benefits for men.

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